This is a great, and beautiful plant. I've eaten the leaves and they taste very good, you're supposed to double or triple boil the leaves in different changes of water. You used to be able to buy the leaves canned up in the southern states in stores, similar to collard greens or mustard greens, up until twenty years ago.
The seeds are not supposed to be crushed, but I've read most either just swallow the whole fruit, or break the fruit with your tongue and swallow the seeds with a glass of water, or spit out the seeds. Last time I ate one, there were three seeds in one fruit. Potentially, there might (?) be some anti-inflammatory properties to the seeds, if swallowed whole, but don't chew them up.
My first experience with this plant, not knowing what it was, it was probably ten years ago, me and a friend crushed a bunch of fruits with our hands so our hands turned a purple cover. I left the juice on for maybe ten minutes and my hands started to get hot and burn, so I washed them off in a nearby stream. That helped a little bit, but my hands were still burning a bit, so I walked to a gas station that was a couple blocks away, and washed them with soap and water.
The berry juice can be made into wine, or mixed with half vinegar and used as an ink, that used to be made many years ago.
This guy out of Florida has about 650 plants in his website. I would recommend anybody learning a lot from this author. http://www.eattheweeds.com/?s=poke+weed
Years later, I am comfortable eating the fruit, one fruit in a day. But on a plant group that is dedicated to this plant, on social media, people mention that it has a 5000 year history of use, and often that they try to educate people about it on other plant group pages and get shamed and insulted saying it's all poisonous and has no use. I've even found the local university page that lists it as a food, copyright 2020, and a picture of the store bought can.
Although the same university has another page that says in 1988, "most authorities regard the plant as poisonous."