The problem with these infections is that they do become systemic in that they create a very hostile environment for the body to deal with. Endocrine and immune changes can be intense which affect all parts of the body. The oxidative stress from the infection causes a lot of tissue damage in itself. Brain behaviors change dramatically from cytokine involvement etc.

Adrenal activity becomes enhanced causing shifts in metabolic rates. Loss of vital electolytes becomes another issue so you see magnesium wasting which causes neuromuscular problems, cardiovascular (palpitations), immune weaking etc.

I would not see why you could not treat either first or last. Identification is key which comes from good and reliable testing. Try ParaWellness labs.