dpk
A little tired tonight. I just wanted to say from past experience I learned a little bit about this recycling and production of atp in glycolysis and the krebs cycle, but it is linked with the nicotinamide reactions.. NADH, NAD, NADPH. The thing that is needed to recycle these reactions and make the energy cycles continue is flavin based enzymes. FAD, FMN all based around b2.. riboflavin..
B2 also changes b6 into p5p, it's more bioactive form.. Converts Niacin to a more active form, powers the glutathione reductase enzyme and reduces Coq10 to Ubiquinol. Probably does some other things I am forgetting too.
I wonder if taking a large amount of CoQ10 would sequester the b2, disallowing the nicotinamides to reduce and oxidise themselves which would block atp generation in both the anareobic and aerobic pathways at the same time slowing the conversion of other b vitamins used in some of the other enzymes.
Also, CoQ10 if I remember correct is one of the only substances that can travel into the inner and outer chambers of the mitochondria. Which would mean it could slow down portions of the kreb cycle preventing optimal atp production.
It's an interesting idea.
It's one explanation. Someone with a biochemistry degree hopefully will chime in and elaborate on it.
David