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Researchers have found a new therapeutic method that may restore damaged myelin sheaths lost during Multiple Sclerosis in a proof-of-principle study published in the journal Cell Stem Cell.
The animal study found that exposing old animals to circulatory systems of young animals may regenerate myelin sheaths surrounding the nerves lost during Multiple Sclerosis.
Aging impairs regenerative potential in the central nervous system, says author Amy J. Wagers, PhD.
Researchers using a surgical technique introduced experimental demyelinating injury in the spinal cord of an old mouse, creating small areas of myelin loss, and then exposing that area to cells found in the blood of young mouse. Immune cells from the young mouse helped old mouse stem cells to restore effective remyelination of the spinal cord.
This means that, in theory, regenerative therapies will work throughout the duration of the disease, said Franklin.
This could be particularly useful, in treating MS, according to the researcher.
This impairment can be reversed, however, suggesting that the eventual development of cell-based or drug-based interventions that mimic the rejuvenation signals found in our study could be used therapeutically, said Franklin.