There are too many factors involved. Pregnenolone, Vit C, certain Bs are probably worth trying for most people; however more than a few very sick people will not tolerate one or another of thos--and so many other supplements. It is understandable that doctors don't usually want to mess with them.
Once people start messing with hormones such as pregnenolone, I think people should get followup tests. Hormone balancing can be wonderfully powerful when done properly, but can cause problems if done irresponsibly.
Do your homework and get well!