Please get the right calcium…! And the reason to take K2 mk4…
(Feb 2008) Dr. Guy Abraham cautions that "excess calcium supplementation (2,000-3,000 mg’s/day) has been the most common cause of poor response to Iodine
supplementation." Vitamin Research News Vol. 22. Number 2.
A new review of research suggests that calcium supplements may trigger heart attacks. Find out which sources of calcium won't.
MK4 is produced via conversion of vitamin K1 in the testes, pancreas and arterial walls. While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK4, studies demonstrate the conversion is not dependent on gut bacteria, as it occurs in germ-free rats and in parenterally-administered K1 in rats. In fact, tissues that accumulate high amounts of MK4 have a remarkable capacity to convert up to 90% of the available K1 into MK4.
In contrast to MK4, menaquinone-7 (MK7) is not produced by human tissue, but is converted from phylloquinone (K1) in the colon by E-coli bacteria. However, bacteria-derived menaquinones (MK7) appear to contribute minimally to overall vitamin K status. MK4 and MK7 are both found in the United States in dietary supplements for bone health.
Stephan Guyenet wrote the link and if you scroll down in the blog discussion you will find what Chris Masterjohn had to say. Chris Masterjohn is one of Stephan Guyenet's sources.
The study on K2 Mk7 about the half life was done by Vendors who sell K2 Mk7. Look closely at what these 2 men say about K2 mk7 and its Half-life. Chris Masterson makes a good point and Stephan who wrote the article is not totally agaist K2 mk7 but he brings up the point about Vendors, who would totally be biased on the K2 mk7.
A few people who take ONLY K2 mk4 have reported calcium reduction in the blood, and for some men an incredible LIBIDO effect, as well as the additional teeth, gums and skin effect that a lot of women report.
Just saying, Forget the studies on K2 mk4 or K2 mk, make your own judgement based on how you feel and calcium content in the serum by a blood test!
I constantly hear people on this site and other sites say that K2 Mk4 makes their teeth, gums and skin feel incredible. I am one of them, from over 3 years ago experiencing it, after starting K2 mk4. I have yet to hear anyone say that about K2 mk7. (not saying no one has, I just have not read it anywhere.) Also, K2 Mk4 removes the calcium from soft tissue and builds bones too.
I plan on taking both but mostly K2 mk4! Torn2Tears
Here are interesting discussions on mk4 vs mk7.
Chris Masterjohn says:
If there were an MK-4/MK-7 combo supplement, I'd probably take it, but I think it makes more sense to go for MK-4 given the choice between the two for the reasons you stated. (The plasma half-life reason is utterly absurd, considering the reduction in plasma half-life is due to the MK-4 being delivered to the tissues where it carries out its functions!) It's also much easier to get MK-7 from the diet in amounts comparable to the supplements, since fermented foods can be quite high in it and the supplements are quite low in it.
(Why is the K2 Mk7 floating around in the body for 3 days?) T2T????
Stephan Guyenet says:
I'm always on the lookout for studies that can shed light on the question of whether MK-4 and MK-7 are equivalent. MK-7 is able to activate clotting factors and osteocalcin, so it can clearly function as a cofactor for gamma-carboxylation in some contexts. Osteocalcin is a Gla protein that's important for bone health. MK-7 supposedly hangs out in the blood for longer than MK-4 in humans, which is one of the things MK-7 supplement manufacturers like to mention, but these findings were conducted by MK-7 supplement vendors and the results have not been published. Interestingly, MK-4 and MK-7 have the exact same plasma half-life in rats, so I think the human experiment should be repeated. In any case, a longer plasma half-life is not evidence for superiority of one form over another in my opinion.
Today, I found another difference between MK-4 and MK-7. I was reading a paper about SXR-independent effects of vitamin K2 on gene expression. The investigators found that MK-4 strongly activates transcription of two specific genes in osteoblast cells. Osteoblasts are cells that create bone tissue. The genes are GDF15 and STC2 and they're involved in bone and cartilage formation. They tested K1 and MK-7, and in contrast to MK-4, they did not activate transcription of the genes in the slightest. This shows that MK-4 has effects on gene expression in bone tissue that MK-7 doesn't have.
Note: You will have to manually type in the site below to see the entire article due to a glitch! Sorry. t2t