Product Details: Bearlic Garlic
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Bearlic Garlic DISCUSSION: Bearlic is Allium ursinum, the wild European "bear's garlic." This unique garlic species contains between two and four times as much of several key phytochemicals (including adenosine, gamma-glutamyl peptides, and ajoenes) as regular garlic. Studies support Alluim ursinum's greater ability to support normal blood pressure balance.
90 Vegi-Caps AOR05023
100% Vegetarian SUPPLEMENT FACTS:
Serving Size: 1 Capsule
%DRI
Allium ursinum concentrate
300mg *
*Dietary Reference Intake not established.
Other ingredients: none. Capsule: hypromellose, sorbitol, silicon dioxide, water.
AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.
Wild garlic is virtually odor-free on the breath.
Suggested Use
Take one capsule two to three times a day, or as directed by a qualified health care practitioner.
Main applications
As reported by literature:
• Cardiovascular support.
• Supports healthy blood pressure.
Source
Wild bear's garlic (Allium ursinum) leaves.
Pregnancy / Nursing
Safe at one capsule a day.
Cautions
• Infants and children should not use the product.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.
Copyright © 2005, Advanced Orthomolecular Research
Bearlic Garlic The common, domesticated garlic created by millennia of selective breeding, sold in supermarket chains, is not the garlic that's found wild in Nature. And it's this common, domesticated garlic (Allium sativum) which is used to make the most readily-available garlic supplements - from the so-called "aged garlics," to the reputedly high-allicin German garlic extracts, and all the way down to the indistinguishable masses of lower-cost but untested garlic pills which crowd health food store shelves. But the true, original garlic of traditional medicine and modern science is Allium ursinum.
Nutrients and Phytochemicals
• Significantly more of many essential nutrients than common kitchen garlic, including such minerals as magnesium, manganese, and zinc.
• Twice the amount of ajoenes, the components of garlic believed to be responsible for garlic's ability to prevent the formation of dangerous blood clots.
• High content of gamma-glutamyl peptides, the phytochemicals responsible for garlic's ability to inhibit angiotensin-converting enzyme (ACE) - the target of the so-called "ACE inhibitor" drugs. Therefore, Allium ursinum is a more powerful natural "ACE inhibitor" than kitchen garlic extracts.
• Twenty-fold higher levels of adenosine. Adenosine works by opening up the ATP-dependent potassium (KATP) channel in the smooth muscles of blood vessels, leading them to relax and present less resistance to the force of the blood flowing through them.
•Various phytochemicals present in Allium ursinum protect adenosine from destruction, allowing a significant amount of it to be absorbed intact.
Bearing the Pressure
Kitchen garlic, and extracts made from it, does appear to have some ability to lower blood pressure, but the effect is weak and inconsistent - hardly surprising, granted that supermarket garlic contains so little of the key phytonutrients which support lower blood pressure. Several studies show that Allium ursinum consistently supports healthy blood pressure, and does a better job than kitchen-garlic supplements.
In one study, the effects of Allium ursinum were tested in animals fed a hypertension-accelerating diet. The diet caused a dangerous 29% increase in the activity of the blood pressure elevating ACE enzyme. Along with it, their blood pressure climbed upward by 8%. Both the increase in ACE activity, and the rise in BP, suffered by the animals receiving the diet but no supplements, were not only stopped, but reversed, by Allium ursinum.
Next, three different garlic extracts (Kyolic®, Kwai®, or wild Allium ursinum) were tested for their effects on BP, with all animals receiving a blood-pressure promoting diet. The animals who got Allium ursinum showed the greatest reductions in blood pressure and ACE activity, followed by those receiving Kwai, while those receiving Kyolic® experienced the least effect on BP and ACE. Of the three garlics, the natural "ACE-inhibitor" power of Allium ursinum was the strongest.
Hope for Hearts In Crisis
Ventricular fibrillation - the fatal loss of the heart's rhythm, reducing a regular drumbeat to a spastic, ineffectual quiver with no power to pump blood - can be the most dangerous part of a heart attack. Ventricular fibrillation begins the process that ends in cardiac arrest. And it's fibrillation that is attacked by defibrillators.
• In one study, rodents were subjected to a simulated heart attack after being fed either regular lab chow, or a diet supplemented with Allium ursinum for eight weeks. After twenty minutes of heart attack conditions, 88% of the untreated animals' hearts had entered into ventricular fibrillation, versus only 20% of the hearts of animals that had received Allium ursinum.
• After the regular flow of blood was restored to the animals' hearts, every single one of the untreated animals' hearts entered into ventricular tachycardia, a condition of wildly racing heartbeat which can lead the heart back into fibrillation; by contrast, 30% fewer animals whose diets had been supplemented with Allium ursinum became tachycardic.
• Significantly fewer of the Allium ursinum-supplemented animals' heart weight actually became ischemic (starved for oxygen) (33.6% vs 40.9% of heart weight).
References
i. Beretz A, Cazenave JP. "Old and new natural products as the source of modern antithrombotic drugs." Planta Med. 1991 Oct; 57(7): S68-72.
ii. Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. "Comparative pharmacological investigations of Allium ursinum and Allium sativum." Planta Med 1992 Feb; 58(1): 1-7.
iii. Mutsch-Eckner M, Meier B, Wright AD, Sticher O. "Gamma-glytamyl peptides from allium sativum bulbs." Phytochemistry. 1992 Jul; 31(7): 2389-91.
iv. Chen CW, Chang HY, Hsiue TR. "Mechanism of adenosine-induced vasodilation in rat diaphragm microcirculation." Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5): H2210-7.
v. Mohamadi A, Jarrell ST, Shi SJ, Andrawis NS, Myers A, Clouatre D, Preuss HG. "Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats." Heart Dis. 2000 Jan/Feb; 2(1): 3-9.
vi. Preuss HG, Clouatre D, Mohamadi A, Jarrell ST. "Wild garlic has a greater effect than a cultivated garlic on blood pressure and blood chemistries of rats." Int Urol Nephrol. 2001; 32(4): 525-30.
vii. Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R. "Cardioprotective actions of wild garlic (allium ursinum) in ischemia and reperfusion." Mol Cell Biochem. 1993 Feb 17; 119(1-2): 143-50.
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.
Copyright © 2005, Advanced Orthomolecular Research
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Exploring Allium species as a source of potential medicinal agents.
Phytother Res. 2006 Jul;20(7):581-4.
Stajner D, Milic N, Canadanovic-Brunet J, Kapor A, Stajner M, Popovic BM.
It has been shown that Allium species may help to prevent tumor promotion, cardiovascular diseases and aging; all processes that are associated with free radicals. Therefore the Allium species of both cultivated species (Allium nutans L., Allium fistulosum L., Allium vineale L., Allium psekemense B. Fedtsch, Allium cepa L., Allium sativum L.) and wild species (Allium flavum L., Allium sphaerocephalum L., Allium atroviolaceum Boiss, Allium schenoprasum L., Allium vineale L., Allium ursinum L., Allium scorodoprasum L.) from various locations were investigated for their antioxidative properties. The leaves were examined for activities of antioxidative enzymes (catalase, peroxidase, superoxide-dismutase, glutathione-peroxidase), non-enzymic antioxidants (reduced glutathione and total flavonoids), content of soluble proteins, vitamin C, carotenoids, chlorophylls a and b, as well as the quantities of malonyldialdehyde and *OH and O2*- radicals. Using a contemporary spectroscopic fluorescent method, lipofuscin, 'plant age pigments' were determined. ESR spectroscopy was used to follow the decrease of oxygen radicals in the presence of extracts of Allium species in phosphate buffer (pH 7). The results showed that all Allium species had strong antioxidative properties due to their high concentration of total flavonoids, high content of carotenoids and chlorophylls, and very low concentrations of toxic oxygen radicals. ESR signals of DMPO-OH radical adducts, in the presence of Allium extracts in phosphate buffer (pH 7), were reduced by up to 94.3%.
Old and new natural products as the source of modern antithrombotic drugs.
Planta Med 1991 Oct; 57(7): S68-72.
Beretz A, Cazenave JP.
Natural compounds have been the first historical source of antithrombotic compounds (heparin, vitamin K antagonists, streptokinase, urokinase); molecules extracted from plants or animals still provide some of the most original and promising approaches for the discovery of new drugs in this class. In this review, we will briefly describe three examples of current research trends that could lead to the development of new antithrombotic drugs of natural origin. Flavonoids have been shown to be inhibitors of cyclic nucleotide phosphodiesterase; this enzymatic activity is one of the main mechanisms of inhibition of aggregation of blood platelets by flavonoids. Some of these compounds could represent templates for the development of new inhibitors of platelet activation. Garlic (Allium sativum) has been shown to inhibit platelet aggregation in vivo and in vitro; a number of active principles has now been identified and their mechanisms of action are currently being explored. An ancient remedy, the medicinal leech (Hirudo medicinalis), has been found to contain several potent anticoagulant proteins. Among them, hirudin, a polypeptide of 65 amino acids, has been identified as one of the most potent inhibitors of thrombin. The production of sufficient amounts of hirudin through molecular biology techniques has now allowed the performance of clinical trials. These three examples show that careful consideration of biochemical, ethnopharmacological, or toxicological properties of natural products can still constitute a valuable basis for the development of new drugs.
Comparative pharmacological investigations of Allium ursinum and Allium sativum.
Planta Med 1992 Feb; 58(1): 1-7.
Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H.
Extracts of wild garlic (Allium ursinum) and garlic (A. sativum) with defined chemical compositions were investigated for their in vitro inhibitory potential on 5-lipoxygenase (LO), cyclooxygenase (CO), thrombocyte aggregation (TA), and angiotensin I-converting enzyme (ACE). The inhibition rates as IC50 values of both extracts for 5-LO, CO, and TA showed a good correlation with the %-content of the major S-containing compounds (thiosulfinates and ajoenes) of the various extracts. In the 5-LO and CO test the garlic extracts are slightly superior to the wild garlic extracts whereas, in the TA test, no differences could be found. In the ACE test the water extract of the leaves of wild garlic containing glutamyl-peptides showed the highest inhibitory activity followed by that of the garlic leaf and the bulbs of both drugs. The comparative studies underline the usefulness of wild garlic as a substitute of garlic.
Mechanism of adenosine-induced vasodilation in rat diaphragm microcirculation.
Am J Physiol Heart Circ Physiol 2000 Nov; 279(5): H2210-7.
Chen CW, Chang HY, Hsiue TR.
The mechanism of adenosine-induced vasodilation in rat diaphragm microcirculation was investigated using laser Doppler flowmetry. Adenosine (10(-5), 3.2 x 10(-5), and 10(-4) M), the nonselective adenosine agonist 5'-N-ethylcarboxamido-adenosine (NECA) (10(-8)-10(-7) M), the specific A(2A) agonist 2-p-(2-carboxyethyl)phenyl-amino-5'-N-ethyl carboxamidoadenosine (CGS-21680) (10(-8)-10(-7) M), and the adenosine agonist with higher A(1)-receptor affinity, R-N(6)-phenylisopropyladenosine (R-PIA) (10(-7), 3.2 x 10(-7), and 10(-6) M) elicited a similar degree of incremental increase of microcirculatory flow in a dose-dependent manner. The ATP-dependent potassium (K(ATP)) channel blocker glibenclamide (3.2 x 10(-6) M) significantly attenuated the vasodilation effects of these agonists. Adenosine-induced vasodilation could be significantly attenuated by the nonselective adenosine antagonist 8-(p-sulfophenyl)-theophylline (3 x 10(-5) M) or the selective A(2A) antagonist 4-(2-[7-amino-2-(2-furyl)[1,2, 4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl) phenol (ZM-241385, 10(-6) M), but not by the selective A(1) antagonist 8-cyclopentyl-1, 3-dipropylxanthine (5 x 10(-8) M). Adenylate cyclase inhibitor N-(cis-2-phenyl-cyclopentyl) azacyclotridecan-2-imine-hydrochloride (MDL-12330A, 10(-5)M) effectively suppressed the vasodilator response of adenosine and forskolin. These results suggest that adenosine-induced vasodilation in rat diaphragm microcirculation is mediated through the stimulation of A(2A) receptors, which are coupled to adenylate cyclase activation and opening of the K(ATP) channel.
Effects of wild versus cultivated garlic on blood pressure and other parameters in hypertensive rats.
Heart Dis 2000 Jan-Feb; 2(1): 3-9.
Mohamadi A, Jarrell ST, Shi SJ, Andrawis NS, Myers A, Clouatre D, Preuss HG.
Two separate studies were performed on hypertensive rats to assess the effects of wild, uncultivated garlic on elevated systolic blood pressure (SBP) and other cardiovascular parameters. Also, effects of wild garlic and cultivated garlic preparations were compared and the mechanisms behind pressure-lowering abilities of different garlic preparations were examined. The initial study determined that wild garlic lowers blood pressure. In the second study, cardiovascular effects of three different concentrations of wild garlic and two different cultivated garlics, i.e., a preparation low in allicin and one high in allicin, were compared. All three garlic preparations decreased SBP significantly. Wild garlic produced the greatest pressure-lowering effects, and the least pressure-lowering effects were seen with low-allicin garlic. Compared with control rats, circulating angiotensin II levels were significantly lower in all garlic-eating rats. Losartan decreased blood pressure significantly less and Nw-nitro-L arginine-methyl ester hydrochloride (LNAME) increased blood pressure significantly more in garlic-eating rats than in control rats, suggesting that the renin-angiotensin system (RAS) was less active and the nitric oxide system more active in garlic-consuming hypertensive rats. Accordingly, different garlic preparations, especially wild garlic, favorably influenced high SBP in hypertensive rats. These results suggest that both the RAS and the nitric oxide system are involved in the antihypertensive effects of garlic in hypertensive rats.
Wild garlic has a greater effect than regular garlic on blood pressure and blood chemistries of rats.
Int Urol Nephrol 2001; 32(4): 525-30.
Preuss HG, Clouatre D, Mohamadi A, Jarrell ST.
When groups of 10 Spontaneously Hypertensive Rats (SHR) were fed diets containing either 1% w/w regular garlic (Allium sativum) (AS) or 1% w/w wild garlic (Allium ursinum) (AU) for 45 days, the final mean systolic blood pressure (SBP) was reduced significantly compared to control (C) (C 189; AS 175; Au 173 mm Hg). Compared to C, body weight and circulating glucose and triglyceride levels were not significantly different; but circulating insulin was significantly higher (C 23.6; AS 33.9; AU 29.5 uIU/dl), and total cholesterol was significantly lower (C 133; AS 115; AU 117 mg/dl) in the two groups consuming AS or AU. HDL rose in the two garlic groups, but the differences from C were statistically significant only for the AU group. In a second study, the effects of a lower dose of dietary AS and AU (0.1% w/w) on SBP and various blood chemistries were compared head-to-head in 80 SHR-40 control and 40 test rats. Both AS and AU decreased SBP significantly compared to a control group of 10 SHR followed simultaneously. However, AU at this lower concentration produced a significantly greater SBP-lowering effect compared to the AS group. In addition, AU decreased total cholesterol significantly and tended to increase HDL compared to AS. Accordingly, the results suggest that AU has a greater therapeutic benefit compared to AS at a given concentration.
Cardioprotective actions of wild garlic (allium ursinum) in ischemia and reperfusion.
Mol Cell Biochem 1993 Feb 17; 119(1-2): 143-50.
Rietz B, Isensee H, Strobach H, Makdessi S, Jacob R
The susceptibility to ventricular arrhythmias under the conditions of cardiac ischemia and reperfusion was investigated in the Langendorff heart preparation of rats fed for eight weeks a standard chow enriched with 2% of pulverized wild garlic leaves. The isolated hearts were perfused with a modified Krebs-Henseleit solution. The incidence of ventricular fibrillation (VF) during 20 min occlusion of the descending branch of the left coronary artery (LAD) was significantly reduced in the wild garlic group as compared to untreated controls (20% vs 88%). The same holds for the size of the ischemic zone (33.6% vs 40.9% of heart weight). In the reperfusion experiments (5 min after 10 min ischemia), ventricular tachycardia (VT) occurred in 70% of the wild garlic group vs 100% in untreated controls and VF in 50% vs 90%. The time until occurrence of extrasystoles, VT or VR was prolonged. No significant alterations in cardiac fatty acid composition could be observed. Although the prostacyclin production was slightly increased in hearts of the wild garlic group, inhibition of cyclooxygenase by acetylsalicylic acid (ASA; aspirin) could not completely prevent the cardioprotective effects suggesting that the prostaglandin system does not play a decisive role in the cardioprotective action of wild garlic. Furthermore, a moderate angiotensin converting enzyme (ACE) inhibiting action of wild garlic was found in vitro as well as in vivo that could contribute to the cardioprotective and blood pressure lowering action of wild garlic. Whether a free radical scavenging activity of wild garlic is involved in its cardioprotective effects remains to be established.
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.
Copyright © 2005, Advanced Orthomolecular Research
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