It should be dependent on what else you are on. You don't want to strong of a mixture, the die off might be too strong. For me, I have a level of dieoff I can handle and sometimes I vary other herbs/spices in exchange of something else. For example, if I might take one pill of my regular herbs (paragon) and another pill of olive leaf extract. I find mixing it up helps them from not adapting to what I am exposing them too.