Aluminum interferes with iron too:
Anemia
Anemia may result, due to the interference of aluminum with iron metabolism.
The Iron/Aluminum Connection
The ionic radius of aluminum closely resembles that of iron and the hydrolysis behavior of Al3 and Fe3 in aqueous solution are also very similar. Aluminum follows the iron pathway in the extracellular environment in being bound to the iron transport proteins transferrin and lactoferrin. (The Lancet, October 29, 1988, P. 1008)
In our research, we have repeatedly noted a direct correlation between iron and aluminum levels on tissue mineral tests. If aluminum can displace iron, this may impair critical iron-bearing enzyme systems, including the catalase system and the electron transport system. Defects in either system could cause cellular dysfunction and destruction.
http://www.arltma.com/AlzheimerDoc.htm
Sidenote- that also makes sense with the calcium and magnesium being high, which is an indicator of thyroid/parathyroid (regulates calcium) Again, not a deficiency, but not being utilized as needed- displaced. Aluminum is also involved with that too.
Calcium Deficiency
A calcium deficiency may directly cause symptoms in Alzheimer's disease, or may be important indirectly by allowing aluminum to accumulate in brain cells.
Parkinsonism dementia and amyotrophic lateral sclerosis are neurodegenerative diseases that are endemic among Guamanian and Kii Peninsula Chamorro Indians and are characterized by neurofibrillary tangles. These endemic diseases have epidemiological features that strongly indicate that environmental factors may play an important role. The soils of these areas are particularly rich in aluminum and iron, while deficient in calcium and magnesium.
There are indications that aluminum increases parathyroid activity that reduces calcium levels and causes calcium to be withdrawn from brain tissue. The loss of brain calcium may be the major cause of Alzheimer's disease.
Mayor and coworkers reported that increased parathyroid hormone activity can increase intestine and brain absorption of aluminum.
Dialysis patients, in particular, display increased fractures when their drinking water is high in aluminum and low in calcium. The exact mechanism for the mineralization problem is unknown. It appears that aluminum affects the activity of alkaline and acid phosphatase and modifies the response of these enzymes to parathyroid hormone and vitamin D.
The calcium/aluminum connection could help explain why other biochemical imbalances which interfere with calcium metabolism - lead poisoning, phosphates in soda pop, copper imbalance, manganese deficiency which affects thyroid function, etc., could contribute to the causation of Alzheimer's disease.
Magnesium Deficiency
A principal way that aluminum appears to express toxicity is that it replaces magnesium ions at critical target sites in the cell.
"...chemically, aluminum is quite similar to magnesium... aluminum can compete effectively for magnesium binding sites in biological systems... aluminum binding to ATP is 7 to 10 times stronger than magnesium, so even at very low concentrations (nanmolar) aluminum can potentially interfere with magnesium-dependent systems..." Berthoff, pp 250
"The relative binding strengths of the ligands will determine the pathway of aluminum in vivo and its competition with other metal ions such as Mg2. For example, the hexokinase reaction is the first step in the metabolism of glucose in which ATP-Mg is involved in the formation of glucose-6-phosphate. In vitro, aluminum inhibits this reaction by binding to ATP 10 times more strongly than Mg2, forming inactive ATP-Al. However, activity is restored in the presence of citrate because citrate binds aluminum 20 times more strongly than ATP. (The Lancet, Oct. 29, 1988, p.1008)
Garruto et al. have suggested that hyperparathyroidism secondary to calcium and magnesium deficiency may enhance aluminum absorption. The role of parathyroid status in aluminum accumulation in dialysis patients has been much debated, but no consistent relationship has emerged from the data.