The efficacy of vitamin C depends on more than just absorption potency. Factors such as speed and substrate characteristics also plays a big role especially in those with advance weakness and those who are sensitive. Properly dosed vitamin C cocktails is thus a most ideal way to ensure proper nurturing.Like antibiotics, cocktails are often use in advance case to be most effective. Those with very mild adrenal fatigue may not appreciate this because their body is strong relatively speaking. Your question is a good one.