I am now into advance stages of investigating chronic health issues involving multiple symptoms for some time now.
I work by studying samples on a microscopic level.
One big problem is parasitic forms that involved specific tissue or cells, and have genetic material that end up in circulation. Many times, the cells that pick them up become active, and release mediators and toxins into the blood stream.
Plus, there are chemicals produced by the foreign object\microbe that can direct cell behavior or release their own toxins\mediators.
Dsybiosis is far more complicated than is currently known.
Most start from latent or active parasitic form somewhere in or on the body. Tooth infections can be painless, but have far reaching physiological consequences, for example.
The range of identifiable microbes are small. The number of unidentifiable microbial parasites
is very extensive.
Fungal and bacterial co-infections are almost always an issue with any parasitic form 'including' viruses.
I define "parasite" as any foreign microbe\virus\protein that initiates immunological dysfunction in a living host. Host cells and proteins can also be defined in this way under certain circumstances.