I took 4 an hour before bed, that seemed to work. While I didn't actually sleep, my body melted into my mattress and I didn't toss and turn like usual. I usually have tension and RLS, but this was a very comfortable rest for my body.
I love this product works great. Many times I will go to bed and not fall asleep right away then I realize my mind is racing...go take 2, and boom out go the lights in about 15 min. Don't be afraid to experiment. My wife takes them too, and she has to take more than I do, but work good for her.