It is fine to take medications and supplements while on a bowel cleanse...just make sure that you take them at least an hour before or after you take psyllium and/or Bentonite so the cleanse doesn't interfere with the absorption of meds/supps. Regarding medications, only take what is absolutely necessary. Avoid OTC meds when possible and try to deal with symptoms in a more natural way. Also, pay close attention to how your body is responding while on any cleanse...some people find it necessary to adjust their medication dosage as their body detoxes and they become more healthy.