just start taking it. start off slow. feel the burn, baby! take it with meals to keep from feeling it too much int he stomach. build up to what you want to take. i like a teaspoon a day of 180,000hu. i will let you do the math. i take it mixed with other herbs and not necessarily all at once. one time it felt like i was having a heart attack(pain in stomach. i took it on an empty stomach without enough water. you have to do one or the other. it wont hurt you, but it can feel like it is.