See also https://www.curezone.org/forums/m.asp?f=738&i=3163#i
The mechanism by which oregano attacks unwanted fungi etc. is thought to be by damaging the cell membrane. This happens in daily levels of 600mg; NOTE not
a teaspoonful from a liter bottle! It is being looked at as a part of a drug delivery system (at the cellular level from this property).
Carvacrol and thymol are considered to be somewhat synergistic so the oil with the Maximum level of carvacrol (70%) may not be the best oil in terms of theraputic value.
There is also evidence of reduction in platelet aggregation and an affect on collagen but I can't ascertain if these are good or bad.
Possibly the large doses you have been taking are increasing the permiability of all your cells including your skin. Increased permeability would screw up the ion balance etc.
Compounds in Oregano
There are dozens, including thymol, sabinene hydrate, aristolochic acid, and carvacol.
Most important are considered Thymol and Carvacrol.
Most of the oregano sold in the United States is grown in Mexico (Genus Lippia).
In case your source comes from here and not wild oregano
Lippia graveolens, Verbenaceae, Mexican oregano, essential oil composition, p-cymene, 1,8-cineole, γ-terpinene, thymol, carvacrol
The wild oregano spice includes various plant species. The most common are the genus Origanum, native of Europe, and the Lippia, native of Mexico. Among the species of Origanum. their most important components are the limonene, gamma-cariofilene, rho-cymenene, canfor, linalol, alpha-pinene, carvacrol and thymol. In the genus Lippia, the same compounds can be found. The oregano composition depends on the specie, climate, altitude, time of recollection and the stage of growth.
Oregano oil is absorbed into the body tissue and exerts an anti-oxide affect delaying lipid oxidation but not as good as vitamin E.(rabbits)
Human study (probably the only one so far)
Inhibition of enteric parasites by emulsified oil of oregano in vivo.
Phytother Res. 2000 May;14(3):213-4.
Oil of Mediterranean oregano plant - Oreganum vulgare - was orally administered to 14 adult patients whose stools tested positive for enteric parasites, Blastocystis hominis, Entamoeba hartmanni and Endolimax nana. After 6 weeks of supplementation with 600 mg emulsified oil
(so DON'T think more is so much better) of oregano daily, there was complete disappearance of Entamoeba hartmanni (four cases), Endolimax nana (one case), and Blastocystis hominis in eight cases. Also, Blastocystis hominis scores declined in three additional cases. Gastrointestinal symptoms improved in seven of the 11 patients who had tested positive for Blastocystis hominis. Oregano oil research wild oregano plant.
'Other studies have shown that the same phenolics (inc. thymol and carvacrol)nettie's note
have negative attributes such as carcinogenic activity and antinutritional activity, as well as imparting negative attributes to foods'
I do not have access to this paper. This is from the synopsis.
This may be an interesting book for you bibliophiles.
'The Constituents of Medicinal Plants: An Introduction to the Chemistry and Therapeutics of Herbal …'