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Melatonin can help prevent Migraines

I also suffer from migraines, and have found that supplementation with melatonin to prevent symptoms of functional (non-ulcer) dyspepsia has also reduced my migraines somewhat.

Date:   12/15/2013 9:45:20 PM   ( 7 y ) ... viewed 3138 times

At the American Academy of Neurology 65th Annual Meeting, sleep researchers from the São Paulo Headache Center presented results from a multicenter, randomized, double-blind, placebo-controlled trial assessing the ability of melatonin to prevent migraine headaches.

A total of 178 men and women met the International Headache Society diagnostic criteria for migraine with and without aura and had 2-8 migraine attacks per month.

Participants were randomly assigned to 3 mg of melatonin, 25 mg of amitriptyline, or placebo for 3 months. Medications were taken between 10:00 PM and 11:00 PM daily.

The primary outcome was the reduction in the number of headaches per month. Secondary endpoints included migraine intensity and duration and analgesic use. Tolerability was also measured in all 3 study groups.

The mean reduction in headache frequency was 2.7 in the melatonin group, 2.18 in the amitriptyline group, and 1.18 in the placebo group. The proportion of responders was greatest in the melatonin group at 54% vs 39% for amitriptyline and 20% for placebo.

Melatonin was very tolerable and associated with fewer adverse effects compared with amitriptyline.

Patients gained weight in both the amitriptyline and placebo groups, but melatonin was associated with weight loss.

The researchers rated the study's findings as promising and warranting further research.

Medscape Neurology Minute - May 2013

More information:
"The Therapeutic Potential of Melatonin in Migraines and other Headache Types":

Joel J. Gagnier, ND
Alternative Medicine Review ◆ Volume 6, Number 4 ◆ 2001
Copyright©2001 Thorne Research, Inc.

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