IBS - Inflammatory Response, and Histidine.
Prolonged inflammatory response in IBS - cytokines and mast cells - visceral hypersensitivity.
Date: 8/21/2012 8:37:55 PM ( 9 y ) ... viewed 2797 times
Just an update.
I am still experiencing diarrhea in the morning only but also quite a lot of gut pain in the morning and through the day. Some days I feel depressed and think the parasites have come back. I know they haven't though as I do have more energy and when I am strictly following the Low-Fodmap diet, I don't have many symptoms.
I wish I could get rid of the nasty belching at night when I lie down. I think this is due to the motility issues/hydrochlorhydria caused by the original protozoan infection.
I did get some sense of hope from new research which suggests that, particularly in post-infective IBS patients, there are increased numbers of inflammatory cells found in the lining of the large intestine and the ileum part of the small intestine. These are actually the places where I feel the bulk of my gut pain.
Mast cells produce cytokines - a type of protein - to fight infection. The release of cytokines cause abdominal pain, cramping and diarrhea. After the infection is conquered, the inflammatory process closes down. In some cases of IBS however, the inflammatory process continues even long after the infection is gone.
Mast cells are located very close to nerve cells in the intestines, perhaps contributing to the ongoing pain, motility dysfunction, and visceral hypersensitivity which is typical of IBS.
The above information dovetails with the personal account listed by Jan McAlister on IBS Tales (2004) where she has successfully treated post-infectious IBS with histidine and zinc. I will try this next & keep people posted on success/failure of above treatment for myself.
See Jan McAlister's post on IBS Tales for the details: http://www.ibstales.com/diarrhea_tales_eight.htm
(The tale of...Jan (May 2004)
Also interesting thing is that I tick pretty much all of the factors which indicate that I would have got post-infective IBS, after the parasites I had were successfully removed.
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