Serrapeptase is a strong enzyme and there have been statements made about it reducing the biofilm. One must be cautious when addressing biofilms.
There was a post about someone who suffered with protozoa and he mentioned that he addressed the biofilm first then use naturals to kill the infection. I would suspect this would depend on each situation. Others on that thread took drug combinations and killed the infection.
The issue with pharmas is that combinational drugs usually are the way to go but which combination kills them is another issue. Alinia and Paromomycin is one of many combinations that can be tried. Alinia is a new drug with fewer side effects. Paromomycin is an older drug that works as a lumicidal drug meaning it kills bugs hidden in the lumen.
Sure I felt sick but more nausea. You have to adjust to tolerance. As I mentioned, protozoa can be stubborn and one person made a wise statement by saying that you have to keep pressure on them, that is my experience.