Sweet Potato Greens Extract - Where to buy?
Forum: Prostate Cancer Forum
View Current Issue (Volume 32 Issue 11 November 2011)
LATEST ARTICLESPolyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo
Karna, P., Gundala, S. R., Gupta, M. V., Shamsi, S. A., Pace, R. D., Yates, C., Narayan, S., Aneja, R.
Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vegetables including spinach. The polyphenol-rich SPGE exerts significant antiproliferative activity in a panel of prostate cancer cell lines while sparing normal prostate epithelial cells. Mechanistically, SPGE perturbed cell cycle progression, reduced clonogenic survival, modulated cell cycle and apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo. SPGE-induced apoptosis has a mitochondrially mediated component, which was attenuated by pretreatment with cyclosporin A. We also observed alterations of apoptosis regulatory molecules such as inactivation of Bcl2, upregulation of BAX, cytochrome c release and activation of downstream apoptotic signaling. SPGE caused DNA degradation as evident by terminal deoxynucleotidyl transferase-mediated dUTP-nick-end labeling (TUNEL) staining of increased concentration of 3′-DNA ends. Furthermore, apoptotic induction was caspase dependent as shown by cleavage of caspase substrate, poly (adenosine diphosphate-ribose) polymerase. Oral administration of 400 mg/kg SPGE remarkably inhibited growth and progression of prostate tumor xenografts by ∼69% in nude mice, as shown by tumor volume measurements and non-invasive real-time bioluminescent imaging. Most importantly, SPGE did not cause any detectable toxicity to rapidly dividing normal tissues such as gut and bone marrow. This is the first report to demonstrate the in vitro and in vivo anticancer activity of sweet potato greens in prostate cancer.
ChAchlorogenic acidJC-15,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol-carbocyanine iodideMSmass spectrometryPARPpoly (adenosine diphosphate-ribose) polymeraseSPGsweet potato greenSPGEsweet potato greens extract
© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: firstname.lastname@example.org
Copyright 1999 - 2015 www.curezone.org
0.086 sec, (2)
High Blood Pressure?
How 3 easy exercises drop blood pressure below 120/80 as soon a...
Filter Your Filthy Water With This
Discover how you can turn the dirtiest water into t...
What is Nascent Iodine?
What is Nascent Iodine? How does it work? Click to learn Iodin...
Free Book by Dr. Clark!
Bestselling author Dr. Hulda Clark claims to have cured cancer...
Clarkia Parasites Cleanse
Hulda Clark Cleanse
Iodine Supports Thyroid Health
#1 Rated Iodine Supplement! 180-Day Money Back Guarante...
Cancer’s Natural Enemy
Opc Oleander, 15% Discount With Curezone Discount Code Of Lr001
Doctors Best-Kept Secret
7 things your doctors would never tell you about your illness...
Anti Cancer Water
Drink millions of medically studied and proven anti cancer ions in e...
Proven Parasite Diet
The Only Legitimate Diet for Destroying Parasites in 30 Days or L...
The Simplest Zapper
The Easiest Zapper to Use! Only $35 With Free Shipping!
Natural Cancer Remedies
$0 Down Solar Systems!
Click to learn more...
Detoxify and Cleanse Naturally
Drink ionized alkaline waters medically proven health b...
The Most Powerful Detox
The Best Detox Article Ever Written.
No More Candida
ProbiCell™ Eradicates Candida Albicans with Probiotics, Prebiotics & E...
The Tesla Shield™
Transformational Technology For Mind Body And Soul.
Worlds leading fungal treatment
Clinically proven effective against thrush, yeast infe...
Native Remedies - People & Pets
Extensive line of herbal and homeopathic remedies for ...
Lugol’s Iodine Free S&H
J.Crow’s® Lugol’s Iodine Solution. Restore lost reserves.
Remove Mucoid Plaque
Remove the black gunk now with organic herbs and clay.
My cancer is gone!
After a single session!
Your Ad Here