Sweet Potato Greens Extract - Where to buy?
Forum: Prostate Cancer Forum
View Current Issue (Volume 32 Issue 11 November 2011)
LATEST ARTICLESPolyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo
Karna, P., Gundala, S. R., Gupta, M. V., Shamsi, S. A., Pace, R. D., Yates, C., Narayan, S., Aneja, R.
Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vegetables including spinach. The polyphenol-rich SPGE exerts significant antiproliferative activity in a panel of prostate cancer cell lines while sparing normal prostate epithelial cells. Mechanistically, SPGE perturbed cell cycle progression, reduced clonogenic survival, modulated cell cycle and apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo. SPGE-induced apoptosis has a mitochondrially mediated component, which was attenuated by pretreatment with cyclosporin A. We also observed alterations of apoptosis regulatory molecules such as inactivation of Bcl2, upregulation of BAX, cytochrome c release and activation of downstream apoptotic signaling. SPGE caused DNA degradation as evident by terminal deoxynucleotidyl transferase-mediated dUTP-nick-end labeling (TUNEL) staining of increased concentration of 3′-DNA ends. Furthermore, apoptotic induction was caspase dependent as shown by cleavage of caspase substrate, poly (adenosine diphosphate-ribose) polymerase. Oral administration of 400 mg/kg SPGE remarkably inhibited growth and progression of prostate tumor xenografts by ∼69% in nude mice, as shown by tumor volume measurements and non-invasive real-time bioluminescent imaging. Most importantly, SPGE did not cause any detectable toxicity to rapidly dividing normal tissues such as gut and bone marrow. This is the first report to demonstrate the in vitro and in vivo anticancer activity of sweet potato greens in prostate cancer.
ChAchlorogenic acidJC-15,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol-carbocyanine iodideMSmass spectrometryPARPpoly (adenosine diphosphate-ribose) polymeraseSPGsweet potato greenSPGEsweet potato greens extract
© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: email@example.com
Copyright 1999 - 2015 www.curezone.org
0.234 sec, (2)
4 Day Liver Detox
I found relief from toxic liver problems in just 4 short days! Check...
High Blood Pressure?
3 easy exercises drop blood pressure below 120/80 as soon as toda...
Detox Your Body
Remove fluoride and heavy metal from your body with this solution!
Iodine Supports Thyroid Health
#1 Rated Iodine Supplement! 180-Day Money Back Guarante...
Clark Bowel Cleanse
Dr. Hulda Clark’s Bowel Program (Intestinal Cleanse). Pure product...
Tapeworms, Round worms, Flukes?
Hulda Clark Cleanses
Eliminate Parasites Now!
The Only Legitimate Diet for Destroying Parasites in 30 Days ...
What Are Probiotics?
Can They Help You? Learn All About Them
Utopia Silver Supplements
Silver Bulletin e-News Magazine, ”What the Coming Food Colla...
Cure Arthritis Joint Pain
Imagine life without joint pain
What Causes Anger?
Anger is all about control and/or not being in control. It is the o...
Natural Cancer Remedies
Detoxify and Cleanse Naturally
Drink ionized alkaline waters medically proven health b...
The Tesla Shield™
The #1 Personal Energy Enhancement Device. Transformational Technolo...
Amazing Oleander-Based Skin Cream
The best ever age defying skin cream for wrinkles an...
J.Crow’s® Lugol’s Iodine
Free S&H.Restore lost reserves.J.CROW’S®Lugol’s Iodine Solut...
Best Candida Treatment?
Probiotics, prebiotics and enzymes.
Complete Candida Cleanse
Restore your health 100% effective Candida Cleanse
Heavy Metal Detox Kit
Removes heavy metals from the body
Your Ad Here