Sweet Potato Greens Extract - Where to buy?
Forum: Prostate Cancer Forum
View Current Issue (Volume 32 Issue 11 November 2011)
LATEST ARTICLESPolyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo
Karna, P., Gundala, S. R., Gupta, M. V., Shamsi, S. A., Pace, R. D., Yates, C., Narayan, S., Aneja, R.
Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vegetables including spinach. The polyphenol-rich SPGE exerts significant antiproliferative activity in a panel of prostate cancer cell lines while sparing normal prostate epithelial cells. Mechanistically, SPGE perturbed cell cycle progression, reduced clonogenic survival, modulated cell cycle and apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo. SPGE-induced apoptosis has a mitochondrially mediated component, which was attenuated by pretreatment with cyclosporin A. We also observed alterations of apoptosis regulatory molecules such as inactivation of Bcl2, upregulation of BAX, cytochrome c release and activation of downstream apoptotic signaling. SPGE caused DNA degradation as evident by terminal deoxynucleotidyl transferase-mediated dUTP-nick-end labeling (TUNEL) staining of increased concentration of 3′-DNA ends. Furthermore, apoptotic induction was caspase dependent as shown by cleavage of caspase substrate, poly (adenosine diphosphate-ribose) polymerase. Oral administration of 400 mg/kg SPGE remarkably inhibited growth and progression of prostate tumor xenografts by ∼69% in nude mice, as shown by tumor volume measurements and non-invasive real-time bioluminescent imaging. Most importantly, SPGE did not cause any detectable toxicity to rapidly dividing normal tissues such as gut and bone marrow. This is the first report to demonstrate the in vitro and in vivo anticancer activity of sweet potato greens in prostate cancer.
ChAchlorogenic acidJC-15,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazol-carbocyanine iodideMSmass spectrometryPARPpoly (adenosine diphosphate-ribose) polymeraseSPGsweet potato greenSPGEsweet potato greens extract
© The Author 2011. Published by Oxford University Press. All rights reserved. For Permissions, please email: email@example.com
Copyright 1999 - 2015 www.curezone.org
0.170 sec, (2)
High Blood Pressure?
3 easy exercises drop blood pressure below 120/80 as soon as toda...
Powerful Healing Water
Learn how to transform your drinking water back to its pristine...
Free Liver & Gallbladder
Free Clark DVD!
A rare interview with Dr. Hulda Clark on DVD for FREE. Patients give t...
Original Hulda Clark
Free Shipping on orders over $49
Discount Colon Cleanse
I Got The Best Colon Cleanse, Shipped To My House For Free! Hur...
Destroy Parasites Quickly
Learn How to Destroy Parasites And Be Free of Your Unbearabl...
Skin Therapy Soaps
Silver Aloe-Aloe Gold-Copper Aloe Skin Therapy Soap. All Natural wi...
Liquid Weight Loss
Lose weight fast with naturally detoxifying antioxidant cleansing l...
The Simplest Zapper
The Easiest Zapper to Use! Only $35 With Free Shipping!
What Causes Anger?
Anger is all about control and/or not being in control. It is the o...
Natural Cancer Remedies
What is Kangen Water?
Is Kangen water beneficial? Why is it so expensive?
The Krill Miracle™
Concentrated Omega 3, 6 & 9, Many Times More Powerful than Fish Oil...
Probiotics with prebiotics and enzymes.
The Tesla Shield™
Transformational Technology For Mind Body And Soul.
Worlds leading fungal treatment
Clinically proven effective against thrush, yeast infe...
Lugol’s Iodine Free S&H
J.Crow’s® Lugol’s Iodine Solution. Restore lost reserves.
Herbal Colonic Program
Cleanse your entire digestive system.
Your Ad Here