I submit that there is a difference between plants created via selective breeding and cross pollination - as could have occured in nature - and those which man has created via trans species genetic transplanted material, artificial gene manipulation and and other unnaturally created plant and animal forms.
What my ancestors ate a thousand years ago and what was around a thousand years ago may have little resemblance to today, but is has everything to to with what I might be able to adapt to eat today. I probably eat healthier than 90% of the folks around, and I could eat a lot healthier still. I do try to avoid unhealthy foods and GMO items. Such as soy.