Cystic fibrosis is a ***genetic disease*** that is associated with abnormal sweat electrolytes, sino-pulmonary disease, exocrine pancreatic insufficiency, and male infertility. Insights into genotype/phenotype relations have recently been gained in this disorder. The strongest relationship exists between ‘severe’ mutations in the gene that encodes the ***cystic fibrosis transmembrane regulator (CFTR) and pancreatic insufficiency. The relationship between ‘mild’ mutations, associated with residual CFTR function, and expression of disease is less precise. Atypical ‘mild’ mutations in the CFTRgene have been linked to late-onset pulmonary disease, congenital bilateral absence of the vas deferens, and idiopathic
pancreatitis. Less commonly, sinusitis, ***allergic bronchopulmonary aspergillosis***, and possibly even asthma may also be associated with mutations in the CFTRgene, but those syndromes predominantly
reflect non-CFTRgene modifiers and environmental influences.
>>On strains and forms: not much point in knowing the strain? Are you kidding? Their vulnerabilities and resistances to azoles and other meds are well-known and googleable. Forms? Ok, yeah, useful to know what exactly you're trying to cure and how long to expect results in or switch treatments, true.
I knew that would be misunderstood. Indeed correct, but unfortunately BP has not come to recognize "specific species" importance (susceptability, resisitence, adaptability, ability to mutate and attract other organisms, etc.). Scientists have, MD's have not, and it isn't in the $interests$ of Big Pharma - which has the schmedical community and the FDA by the testes. Collusion at its finest.