Dr. Guy formulated a theory that most disease conditions, acute infections, anemias, metabolic disturbances and malignant cell overgrowths are the direct results of changes in the hydrogen-ion content of the lymph of the body which produces blockage of the lymph channels. In his studies of the growth of corn and other forms of vegetable life, he had been able to demonstrate that the absence of sufficient potassium salts in the soil would result in stunted growth, and evidence of precipitation of minute particles of iron and other substances in the stalks. When potassium was added, the growth proceeded normally; when dilute hydrochloric acid was also added, the growth was further stimulated.
He studied the lymph of a large number of patients suffering from carcinoma, and found that these cases showed a hydrogen-ion much higher than normal individuals. He also found that by administering the salts of potassium in combination with dilute hydrochloric acid, either orally or by the intravenous route, these patients made remarkable clinical improvement, and the hydrogen-ion content of their lymph became normal.
The publication of his series of articles in THE MEDICAL WORLD was followed by a large number of case reports by practicing physicians who greeted the new therapeutic procedure with great enthusiasm. Dr. Guy published his first book on this subject in 1934, and a revision in 1935.