THE ANSWERS TO CURING SENILE CATARACT WERE ALREADY KNOWN IN 1996, AND 1956. ... ... I found an e...
THE ANSWERS TO CURING SENILE CATARACT WERE ALREADY KNOWN IN 1996, AND 1956.
I found an earlier report from 1996. Apparently it is actually an oxidation product of xanthurenic acid, di-oxoxanthurenic acid (DOXA), which leads to crystallin crosslinking and formation of conjugates with glutathione.
"Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans"
"Kynurenine aminotransferase (KAT) transforms 3-hydroxykynurenine into xanthurenic acid"
"Thus, KAT activity seems to be the initial event in senile cataract formation in humans".
Now xanthurenic acid (XA) is listed as insoluble in water, which is obviously the reason for its accumulation in the nucleus of the lens. But I did find a reference from 1956 that XA could be washed out of a chromatography column with a large volume of water:
Does that mean it would be a good idea to drink distilled water on occasion?
Now these authors were studying XA in relation to diabetes, not cataract. Although they found the 8-methyl ether derivative of XA in the urine of non-diabetic people, they say they did not find free XA (much later reports by others however state that XA is excreted in the urine in cases of B6 deficiency). They found production of XA in the body could be suppressed by a liver enzyme which they called "xanthurenicase". Does this mean that senile cataract patients would benefit for example by supplementing with milk thistle? They found that XA could also be suppressed by methionine, by vitamin B6 or by insulin, or by conjugation via agents like glucuronic acid, which is hydrophilic. Hydrophilic conjugation would make it water-soluble, so the body could get rid of it.
It appears however that at least in non-diabetic cataract, we are not (yet) dealing with accumulation of XA in the body, but locally within the eye lens. That is why we need an eye drop that would solubilize XA within the eye lens, and would also block the activity of the "bad" enzyme responsible for senile cataract in the first place - KAT, or kynurenine aminotransferase.
Dissolve XA and its derivatives out of the lens, and block KAT activity in the lens, and you stop nuclear cataract dead in its tracks. Add a crosslink breaker like rosmarinic acid to our eye drop, and the lens may become perfectly clear again.