The cream is made up of natural hormones, such as progesterone, estrogen, testosterone or whatever it is that your body is in short supply of. I've never used it before, but my dad's partner has some that contains natural progesterone. She went to a doctor who specialises in this sort of treatment, and he takes blood tests to analyse what she needs. He then has a pharmacist mix a custom made blend of hormones to suit her. You apply a tiny amount on the areas of your body which don't have much fat, such as your wrist or neck, and I think you do it twice a day, or maybe even just once. My dad's partner uses it because she's had a hysterectomy and she thinks it's great. I guess the best thing about it is the fact it's made to suit your own individual requirements, and it's from natural hormones. I'm going to ring tomorrow and try and get an appointment, because I'm just about going insane with my hormones at the moment. I live in Australia, but I'm sure if you did some googling, you might find someone in your area who can do this. Searching for "natural hormones" might be a good place to start. I've done some research on it a bit and I think it might be the way to go. It's interesting to note the differences between natural and synthetic hormones and how they affect our bodies. I hope this helps. I'll let you know how I go when I've tried it.