Theory: Fatigue is related to methylation problems.
Mechanism: One product of the methylation cycle, SAM-e, is involved in energy production among other things:
SAM-e is a valuable supplement for liver detoxification as it also helps the body produce many methyl-based substances, including: carnitine. creatine phosphate (used in ATP energy production), epinephrine (adrenaline), posphatidyl choline (a nutrient that protects the nerves). Because of this SAM-e may help a variety of liver diseases, inflammatory disorders, depression and elevated levels of homocysteine. It may also reduce intestinal inflammation and protect the brain against free radical damage.
One can be either an over-methylator or an undermethylator.
Sam-e is great for under-methylators because it provides the building blocks necessary to breakdown excess histamine in the body which is a nervous system irritant. If one has excess histamine in the body the adrenals must produce adrenaline to break it down (this is what en epi-pen does). Over time this can cause adrenal fatigue. Just another one of the litany of possible causes.
I don't think Sam-e would be good for overmethylators though, who suffer from a lack of histamine in the blood, which can also cause problems.
I thought I was an under-methylator. And in fact I may be, a low histamine diet and supplementation with methionine did not make a noticeable difference for me, although increased vitamin C supplementation has helped in general. (Vit C breaks down histamine among other benefits).
I do, but I don't exactly know how. methylation has to do with the liver, and heavy metals are so disruptive to the adrenals, liver, and digestive tracts that it seems intuitive to me that an imbalance in one could cause an imbalance in the other. Its difficult to understand the relationships and establish causation though.
That is very true. I am considering TMS and enzymes for my own next supplement purchase because of having read about Sam-E and methylation this past evening. I live currently with 11 amalgams.
While ther is an income on the way for removing these pain-in-the-teeth things, I am doing what I can to improve life quality, though. I read a warning about using MSM because of how easy it is for a methyl to bind with mercury to create a methylmercury (organic mercury), which is the dangerous one for the body... This is how inorganic mercury from Amalgams becomes organic by a conversion process in the gut- the digestion of easy carbs creates a methane byproduct, the mercury mixes with it, and because it has a methyl compound attached, it is absorbed into the bloodstream.
On the other hand, though, a methyl-group supplement properly balanced with B6, B12 and folic acid may balance out the concerns. I'm having snappy joints and such, so I'm taking the material I read seriously. Know anyone who's used SAM-E/MSM/TSM (forms of methyl-compounds)? It's definately liver support I'm shooting for.
Yes exactly, if the methyl is binding to the metals it can leave one being 'under-methylated' surely?
Having had a huge allergic reaction to something unknown (possibly pollen from flower dissection class at school!) the year after i had 4 Amalgams at age 13 - i went into anaphylactic shock - whole body covered in welts, constant vomiting and collapse - the doctor gave me penicillin - i took one pill and went through it all again - the doctor then gave me anti-histamines and i slowly recovered.
I've never taken penicillin since - despite doctors brushing it off as i possibly have 'grown out' of that allergy (they've mistakenly prescribed it despite it being on my records) - i never want to experience ana. shock EVER again.
I now believe high histamine levels - caused by what i don't know - created under-methylation - and the mercury load creating a worse under-methylation state bringing on severe allergy reaction to everything.
Now i'm 34 and never treated histamine/methyl levels and grinding out 2 mercury filling with night-time bruxism - i truly think the Adrenal insufficiency, high histamine, under-methylation, hypothyroid, and heavy metal load/candida is all the result of one root cause.
Is it mercury? It gravitates towards the Pituitary, hypothalamus, thyroid and adrenals. Creates sulfur imbalances, possibly induces methylation problems.
Like many on here - i'm going through tests to determine exactly the level of damage by the (currently) unknown root cause. But i hate to treat the imbalances without knowing the root cause.
Although i believe in supplementation to help us out of the holes we find ourselves in with our health - (i have SAM-e on order) if we don't find out where the true inbalance lies which results in a cascade of imbalances - we'll spend the rest of our lives on supplements treating symptoms and imbalances, which is no different to spending one's life on pharmaceuticals treating symptoms. Although, admittedly supplements don't generally cause as many side-effects and are certainly not as toxic! One still have to be very careful depending on condition of course.