I stumbled upon this document recently and found it very informative, so I want to share it with you! Ladies, please take Pottasium and Magnesium supplements if you are having (or planning to have) Mirena to reduce many of the side effects!
Research and Side Effects
The Mirena has been known to cause a hormonal imbalance in many women. Initially, most women with Mirena, experiencing problems don't realize what is causing them to feel so bad. But with research being done to explore the cause, some doctors are starting to find some answers.
Effects of Levonorgestrel (synthetic form of progesterone: main ingredient of Mirena IUD) in relation to Insulin, Potassium, Magnesium and its consequence in long term use:
Excessive Insulin causes low Potassium : because Insulin promotes Pot. to enter skelettal muscle cells.
9) Leads to: Insulin Resistance: cells don't store Magnesium, lost through urine
Hence less Potassium because Pot. uptake requires Magnesium.
10) Magnesium lack causes blood vessels to constrict: bloodflow decreases: destructive ability of liver enzymes decreases.
11) Insulin causes Sodium retention, leading to even less Potassium.
A decrease in cellular Potassium would (under normal circumstances) cause less Insulin release.
Hence the body initiates more Potassium loss to decrease Insulin release (because the higher the Potassium level, the higher the Insuline release level, but the Insulin levels surge high in spite of Pot. loss because Nat. Prog. is absent/low)
What's essential after stopping Levonorgestrel to normalize levels:
Magnesium & Potassium supplement to kickstart decrease in Insulin release:
To aid pancreas and liver & strict nutritional change in carbohydrates because carb metabolism has altered (proven on Levenorgestrel: elevated Insulin levels).
Increased Potassium would have triggered Insuline release under normal circumstances, but the body is caught in a vicious circle between Synth. Prog imitant, too little or no Nat. Progesterone and a depletion of Potassium and Magnesium, which the body can not fully realise as its natural reaction is to decrease Potassium to lower Insulin: but Potassium has already run dry without taking effect on Insulin on account of Levenorgestrel mimmicking Nat. Progesterone. Levonorgestrel does evidently not perform the function of Natural Progesterone: to decrease and monitor Insulin release, therefore concurrently depletes body of Natural Progesterone and causes Potassium and Magnesium deficiency.
Intracellular Serum levels of Potassium are best tested in form of a hair analysis rather than a blood analysis, as the blood levels are easily influenced by nutrition at the time of taking the blood.
What does Insulin do?
Amongst other functions, Insulin decreases anabolic processes, Glycagon(promotes burning of fat and sugar) and HGrowth hormones (muscle/mass development: decrease leads to premature ageing) are suppressed.
PROGESTERONE DECREASE causes Magnesium and Potassium depletion, decrease in anabolic release, insulin resistance/metabolic imbalance and oestrogen dominance.
Insulin Resistance side effects:
Brain fogginess, poor memory
Low blood sugar
Increased weight/fat storage
Increased blood pressure
Role of Levonorgestrel: Prevents ovulation by mimmicking pregnancy.
No or irregular ovulation leads to a decrease in Natural Progesterone.
Low Nat. Progesterone leads to relative Oestrogen Dominance
Symptoms/effects of Oestrogen Dominance:
Fat cells produce / store oestrogen: weight gain
Sodium/Potassium ratio unbalanced: water retention and bloating
Loss of Magnesium which is essential for Potassium uptake
High blood pressure because of high Insulin level, no Magnesium
Reduction of Oxygen amount in cells
Interference with Thyroid hormnes (ie.Insulin, etc )means: low metabolic rate, low energy, cold intolerance, weight gain
2) Excessively high Aldosterone levels, low Nat. Progesterone: causes excessive loss of urnary Potassium.
3) High Oestrogen levels: elevated Copper levels/Copper Toxicity
4) Already stressed system completely going out of balance in Salt/Potassium ratio
The amount of Aldosterone secreted normally is a direct function of the Serum Potassium. Potassium induces Aldosterone/Cortisol biosyntesis. Potassium should be strongly regulated at all Sodium intakes by Aldosterone when supply of Potassium is adequate. The supply of Potassium when supplementing Levonorgestrel can not be adequate leading to: high Aldosterone, Cortisol, Potassium/Magnesium depletion. Testosterone production may increase as a result, leading to excessive facial/bodily hair growth, head hair loss: masculinalisation.
Diet today is high in Sodium, low in Potassium and Magnesium (highly processed foods, growth soil mineral depletion) and supplemented with Xeno-Oestrogens: Nutritional uptake can not possibly rebalance Pot/Magn deiciencies nor lower Insulin levels. Only a strict protein, complex carbohydrate diet could assist.
Symptoms of Potassium deficiency:
Blood pressure elevation
Heart palpitations, arrythmia
Decreased liver and kidney function
Oestrogen build up
Depression, panic attacks
Levonorgestrel supplementation can lead to all of the side effects (being symptoms of the final conditions stipulated here) above interrelatedly. The long term consequence of usage and following malfunctions and deficiencies are as follows:
Liver disease, tumours
Hormone related cancer (eg. breast)
The symptoms most women exhibit and experience on Levonorgestrel are warning signs of the above mentioned conditions.
Because the cause and effect pathway of the conditions varies in time length and intensity of onset, initial physical constituency of women when starting on Levonorgestrel should be taken into account. The better the physical condition, the longer it might take for initial onset of symptoms, but the symptoms will arise and the conditions will follow.
Most doctors do not seem to be aware of the causal symptoms arising from the longterm use of Levonorgestrel and are therefore incapable of a diagnosis.
Because the symptoms vary greatly, depending on the gravity of the effects of levenorgestrel and their severity in onset, they appear to be non-related and difficult to track.
Levonorgestrel is marketed as safe, especially cost-effective, and good for long-term usage (5 year iud)device. What constitutes the danger is the long term supplementation of levonorgestrel, not necessarily the short-term usage, hence a five year period pescription is irresponsible, to say the least. The manifestation of symptoms and disease is longterm and as varied as the women using it are. Obviously not all symptoms and consequences have been followed in the cause-effect pathway in this text, but the featured ones sum the main complaints of the women seeking help in Mirena forums up.
I hope the above has shown, that all different symptoms arising under Levonorgestrel usage as 5 year IUD do all have a singular cause, should be identifiable by a doctor and have different times of onset and severity depending on the individual's physical constitution, the nutritional habits as well as the amount of exercise of the woman does at the onset and during the taking of Levonorgestrel . Please do not let doctors tell you that your problems stand in no relation to the IUD. Rather tell your doctor to do their homework
Estrogen dominance is a term originally developed by Dr. John Lee, an extensive researcher of the relationships between estrogen and progesterone. The term estrogen dominance describes the condition that occurs in a woman's body when estrogen is the dominate hormone in relationship to its natural counter balance with progesterone. Many people are unaware that women can experience estrogen dominance even with deficient or normal levels of estrogen present in the body. Estrogen dominance in and of itself does not necessarily mean a condition of excessive estrogen. What it does mean is that estrogen is the dominate hormone in its relation to the level of progesterone in the body. So, the overall level of the body's estrogen can be at a normal level, or it can even be at a deficient level, however, if the level of progesterone is also deficient and at levels not sufficient to counterbalance the effects of estrogen, then there will exist the circumstance of estrogen dominance. Estrogen dominance can have a number of causes, especially considering the excessive estrogen (or “estrogen-like” chemical compounds) that are now present in our everyday environment. These include products and substances we're constantly exposed to such as pesticide residue, plastics, meat products, an even furniture. Symptoms of estrogen dominance make for a long list. They include, but are not limited to, the following:
Acceleration of the aging process
Allergies, including asthma, hives, rashes, sinus congestion
Autoimmune disorders such as lupus erythematosis and thyroiditis, and possibly Sjoegren's disease
Cold hands and feet as a symptom of thyroid dysfunction
Decreased sex drive
Depression with anxiety or agitation
Early onset of menstruation
Endometrial (uterine) cancer
Fat gain, especially around the abdomen, hips and thighs
Increased blood clotting (increasing risk of strokes)
Irregular menstrual periods
Premenopausal bone loss
Thyroid dysfunction mimicking hypothyroidism
Water retention, bloating
These were the findings that were found as a result of Dr. Lee's research. For more information on his findings, visit http://www.johnleemd.com/
The findings of Dr. Lee's research go hand in hand with the numerous adverse side effects and reactions that women have reported having as a result of the Mirena, which is thought to be responsible for causing estrogen dominance. Here are just a few of the many side effects women have reported having:
Respiratory Problems(bronchitis, mono, athsma, etc.)
Pain in fingers, hands, arms, legs, etc.
Tingling and Vibration in various parts of the body
Heart Palpitations/Rapid Heartrate
I started to search for the answers when I developed the numbness on the right side of my body (it travelled from the leg, to the arm and then to the right side of my face),with constant headaches and brain fog, all within the first 1.5 month after the insertion. It was a very scary experience. I am otherwise healthy and athletic person, never experienced anything like this before.
I found the website above and took an extra dose of POTASSIUM and MAGNESIUM (on top of my daily multi-vitamin)and my symptoms dissapeared almost instantly.
Hope these findings will be of some help to many womens!
I am in shock at one of the side effects described by one of the women using the Mirena coil. I had the coil inserted 3 years ago after having my 2nd baby four years ago. I accidentally removed it while removing a tampon (I was never told not to use a tampon). While on the coil, i had experienced just about every symptom described in various websites. Terrible back pain (which i tolerated because i have always had back pain for the last 20 years) which was noticeably worse than before, extreme generalized body fatigue always in the mornings, an inability to engage in any form of exercise because of the extreme tiredness and joint pains all over. Unfortunately for me, i felt so much worse removing it most especially with the dysmenorrhoea.
What i find most frightening is what i just read about another person on this forum who has experienced a mysterious numbness on one side of the body.
I had the mirena coil replaced exactly one year ago and 4 months after symptoms which i could not tell if they were worse or just a bit better than when i did not have the coil, i woke up one morning to find the left side of my body completely numb. The only reason why i knew it was not the onset of a stroke was because i could talk and knew i was in no way hypertensive. It also helped that i am a Medical Doctor and felt that this was something i could not readily explain. I was rushed to the hospital and after a CT scan and a Skull x-ray was told i had a kind of arthritis of the bones in my neck (C6/C7) and i had to wear a collar for 2 months afterwards with physiotherapy to regain normal movement on the left side of my body.
With all the posts on the Mirena, my concern has been the fear of the effects of removing it which i am planning to do within the next one month. I will definitely start the Potassium, Magnesium, Calcium combination.
NB: I have put on 10kg since the 2nd insertion, its mainly abdominal and i always look pregnant and nothing seems to be working with a change in my diet since it is so painful to exercise.
I am so glad, i have found some research which i completely understand whether its backed by some scientific research or not because the explanation is plain enough to me especially the link with insulin.
Thank you so much for this information, i'll be sure to spread it as i know so many women suffering silently with the supposedly next best contraceptive in the market.
Mother of 4, thanks for all of this information.
I am 46 and had my second Mirena put in a few years ago. The past year and a half I am a hot mess. All of a sudden allergic to everything I put in my mouth, from soy, dairy, even the products in my milk alternatives. The last month High histamine foods are the newest trigger of bloating, fatigue, rosacea, facial swelling etc. My gut tells me that it is related to the Mirena. I honestly enjoyed not having a period and I believe the hormone has helped with the pms that accompanied the periods, but now I believe I am paying a price. My obstacle is how to safely detox off the thing. My doctor just gives me the deer in the head light look because they really don't know anything about it. When I had the first one removed I was in the hospital with a terrible migraine the following day (and I don't get headaches). Maybe a naturopath may be best.
Thanks again for the info!
First, I would like to say Thank You!!!! I will get on a pot. And mag. regimen tomorrow. How much should I take daily? Does it matter if I take calcium magnesium? Magnesium sterate or citrate? Bananas have a lot of potassium but it seems like I get worst after eating bananas so I stopped eating them but wont hurt to try these 2 supplements along with Vitamin D3 which blood test revealed I'm low. Need to have blood retested for pot. and mag. But again thanks!!! What else do u take? So do you think I have hypothyroidism or body mimicking the problem but the underlying problem is low in pot. and mag.? Just curious in knowing more. Actually have more questions but I will save them for later. Lol lol lol Sorry if I'm intruding or questioning u too much but new revelation gets me excited!!! Thanks again for relying this information...greatly needed!!
Always take Calcium with Magnesium (taking just Calcium without Magnesium can make more harm than good for your bones; up to 50% of your Magnesium is stored in bones, only 1% in the blood). Also, take Magnesium with Vitamin D to help in Calcium absorption by 5 times! Magnesium should also be taken with vitamin B6 to help with the absorption of Magnesium.
The max RDA for Magnesium is 310mg (for females). The best sources are green veggies (spinach), black beans,nuts, seeds, whole grains, fish Halibut.
The most distinctive signs of low Mg are unexplained ulcers in the mouth area. Also, irritability, hypertension, feeling of tightness in chest, allergies, numbness and tingling sensation, osteoporosis, breast tenderness etc.
The max RDA for Potassium is 3500mg. The best sources are: bananas (1 banana=420mg), oranges, strawberries, spinach, tomatoes, potatoes. Signs of potassium defficiency are: thirst and frequent urination, tingling sensation or numbness in exteremities, low blood pressure, anxiety etc.
My multivitamin/mineral supplement has only 50mg of Mg and 7.5mg of Potassium. Therefore, I am taking one extra tablet/day of each, Potassium and Magnesium only, I guess I could take more if needed. Listen to your body and adjust accordingly. The best source should be the food, and when adding extra supplementation, start gradually, because too much it at once can cause the similar side effects as a lack of it.
You can test your blood for Hypothyroism, just in case, but most likely your symptoms are caused by lack of the essential minerals (Mg and Potassium as mentioned above.
I haven't removed it yet, but I am considering it. I just got Mirena 2 months ago. After taking extra Mg and Potassium supplementation my tingling and numbness, along with a constant headaches dissapeared. I developed those symptoms in the very first week after the insertion and had them constantly for more than 1 month.
I need to chime in here on that research, since I was the one that compiled those links. The potassium information came from hormone spiral, which is a translated German forum. I was never able to find out where the information came from so I am not sure how accurate or reliable it is. It does make sense,but without knowing the source of the information, please take it with a grain of salt.
That being said, I hope all of you keep inspiring each other. You are wonderful, strong women, and you will get through this.
Jackie, my heart breaks to see you still suffering so badly. Hang in there, you are in my prayers. Call me if you need to talk.
Please keep spreading the word, and make sure you sign the petition as well. (I tried to no avail to get the moderator to change the link to part II-if anyone knows how to get to him, please do) The more stories on it, the more credible our argument becomes.
your post has literally tied everything together for me in understanding my symptoms. I had the Mirena iud in for 6 year's when I developed severe IBS 2 year's prior to its removal in 2008. I began doing independent research an was convinced it was the iud causing Candida overgrowth . I had the iud removed but suddenly my symptoms became worse. my potassium levels began testing very low and I was sick all the time. everything I ate was coming right back out. 5 Years now I have been suffering with borderline inflammatory bowel disease which caused severe me anxiety and heart palpitations, even begun having svt attacks of 200 bpm. well, it took me 2 year's to even get a potassium prescription to stop the heart rhythms. my insurance won't even pay for the magnesium they prescribed me.
I've been on potassium and magnesium for 2 year's now and my potassium levels were still low. it was just last week I began reading about low progesterone levels caused by estrogen dominance that cause low potassium. so now I am taking progesterone cream 2 Times a day and it is really helping my anxiety and my heart arrhythmias to stop. I am also sleeping again.
I'm just wondering. I don't see any mention in your article about progesterone replacement therapy. it will be very hard for me to see a doctor and explain all this. I think I will be taking your article with me. wish me luck. :)
So much of this post resonates with me and I love it because it gives me the Science behind my symptoms.
I had my Mirena out in July 2013. This was because I had decreased libido, was retaining water, had migraines, more hair on my body, thinning scalp hair, acne on my face and back, constant spotting, brain fogginess, mood swings, irritation of the skin around my labia, sweating uncontrollably etc... So many things and more than I have listed.
The most dramatic change was my BP increased from 100/70 to 148/110. That was scary and straight away I thought, it's the Mirena. All my doctors laughed at me. And I have seen many doctors because of all the problems I have had. That infuriates me because I know what my body felt like before having the Mirena inserted.
After having it removed I also had menopausal symptoms such as vaginal sensitivity, crushing fatigue, hot flashes and sleeplessness. After removal, it took my body eight months to have a period. My hormone levels are still indicative of menopause and I am only 42.
But. There are points in this post that speak to other problems I have been having and I am wondering if they should be attributed to the Mirena too. It is so interesting and frustrating!
I have been recently diagnosed with Gilbert's Syndrome. This is caused by a deficiency in how your liver enzymes process toxins and bilirubin. And then I see your post:
"Magnesium lack causes blood vessels to constrict: bloodflow decreases: destructive ability of liver enzymes decreases."
I also had an ACL reconstruction on my left knee in Sept 2012 (while the Mirena was still inserted). My recovery has been slow despite exercising regularly and following my surgeon's and physio's protocol. I used to feel like the Mirena had caused my whole body to malfunction but I didn't know why. Then I read:
"Amongst other functions, Insulin decreases anabolic processes... HGrowth hormones (muscle/mass development: decrease leads to premature ageing) [is] suppressed."
That is sooo interesting because my vastus medialis, one of my quads, has persistent atrophy. Muscle wasting and loss of mass! That is what is delaying my recovery!!
Also, I was reading some other posts here and I had two other similar neuro-type symptoms. Waking up in the middle of the night feeling like I couldn't breathe and like I could not remember how to breathe. I also had weakness in my hands and arms while on the Mirena and could not pick up a glass because my grip was so weak and my hands were shaking so much. I started wondering if I had MS.
I have been feeling like such a hypochondriac. I am going out to buy some Magnesium and potassium supplements. And I have a vague recollection of my tests showing an abnormal K (potassium) reading. I am going to get all my blood results and have a look at them.
I also remember there were issues with thyroid function that were also new to me.
I keep telling all my doctors that one day there will be evidence-based research that they will listen to about this and I will be able to say, I told you so.
This has been my life for the past two years. It started with edema and then what looked like kidney infections. Then my allergies went off the scale. I started having anaphylactic reactions to fragrance. I then had what presented as a massive heart attack (I was 42). It was later determined to be acute hypersensitivity myocarditis (swelling of the heart caused by allergies). It left me with a murmur. Then I went into Addison's crisis, my adrenal glands were only functioning at about 10% I had a severe sodium deficiency and potassium imbalance. A few months later they determined I also had thyroid dysfunction and low pancreas function. I am now being treated for autoimmune angioedema uticaria (severe swelling and hives caused by allergies that have progressed to an autoimmune stage. I am on a regime of 12 antihistamines a day along with adrenal supplementation, thyroid supplementation, magnesium and vitamin b. I am starting to feel human, but have been on disability for 1.5 years and rarely leave the house for fear of allergic reaction. I also have to nap frequently due to the medication side effects.
The mirena causes serious damage to the female body, and the only way to get rid of these side effects for good is to remove the mirena and take natural supplements, herbs and foods that will eliminate estrogen dominance, help restore the balance of progesterone and estrogen hormones, and detoxify the body from all the toxins present in mirena such as silicone and copper.
It would be nice if you shared your findings instead of sending us the an add. Many of us are suffering with these side effects and have no place to turn as conventional doctors don't seem to understand the effects this IUD has left on women. I have gone to countless people for help. I have found that they all charge and none have helped. ):
There's a very informative site with lots of information on how to lose weight and get rid of the mirena iud side effects and find other natural birth control options. Check out mirenadetox Her detox has also been immensely helpful to my recovery and I seriously recommend it
I have had the mirena coil twice a total of 8 years and have now gone through the menopause at 45 and have had a lot of the symptoms mentioned would it be safer to remove the mirena and use combined hrt? Also should I start taking magnesium and phosphate supplements now!
Brilliant. Thank you so much. 9 months after removal still allergies and tired. This info has really made sense as my physio told me to take magnesium and I wasn't as sore but still always tired and no concentration or energy.