I stumbled upon this document recently and found it very informative, so I want to share it with you! Ladies, please take Pottasium and Magnesium supplements if you are having (or planning to have) Mirena to reduce many of the side effects!
Research and Side Effects
The Mirena has been known to cause a hormonal imbalance in many women. Initially, most women with Mirena, experiencing problems don't realize what is causing them to feel so bad. But with research being done to explore the cause, some doctors are starting to find some answers.
Effects of Levonorgestrel (synthetic form of progesterone: main ingredient of Mirena IUD) in relation to Insulin, Potassium, Magnesium and its consequence in long term use:
Excessive Insulin causes low Potassium : because Insulin promotes Pot. to enter skelettal muscle cells.
9) Leads to: Insulin Resistance: cells don't store Magnesium, lost through urine
Hence less Potassium because Pot. uptake requires Magnesium.
10) Magnesium lack causes blood vessels to constrict: bloodflow decreases: destructive ability of liver enzymes decreases.
11) Insulin causes Sodium retention, leading to even less Potassium.
A decrease in cellular Potassium would (under normal circumstances) cause less Insulin release.
Hence the body initiates more Potassium loss to decrease Insulin release (because the higher the Potassium level, the higher the Insuline release level, but the Insulin levels surge high in spite of Pot. loss because Nat. Prog. is absent/low)
What's essential after stopping Levonorgestrel to normalize levels:
Magnesium & Potassium supplement to kickstart decrease in Insulin release:
To aid pancreas and liver & strict nutritional change in carbohydrates because carb metabolism has altered (proven on Levenorgestrel: elevated Insulin levels).
Increased Potassium would have triggered Insuline release under normal circumstances, but the body is caught in a vicious circle between Synth. Prog imitant, too little or no Nat. Progesterone and a depletion of Potassium and Magnesium, which the body can not fully realise as its natural reaction is to decrease Potassium to lower Insulin: but Potassium has already run dry without taking effect on Insulin on account of Levenorgestrel mimmicking Nat. Progesterone. Levonorgestrel does evidently not perform the function of Natural Progesterone: to decrease and monitor Insulin release, therefore concurrently depletes body of Natural Progesterone and causes Potassium and Magnesium deficiency.
Intracellular Serum levels of Potassium are best tested in form of a hair analysis rather than a blood analysis, as the blood levels are easily influenced by nutrition at the time of taking the blood.
What does Insulin do?
Amongst other functions, Insulin decreases anabolic processes, Glycagon(promotes burning of fat and sugar) and HGrowth hormones (muscle/mass development: decrease leads to premature ageing) are suppressed.
PROGESTERONE DECREASE causes Magnesium and Potassium depletion, decrease in anabolic release, insulin resistance/metabolic imbalance and oestrogen dominance.
Insulin Resistance side effects:
Brain fogginess, poor memory
Low blood sugar
Increased weight/fat storage
Increased blood pressure
Role of Levonorgestrel: Prevents ovulation by mimmicking pregnancy.
No or irregular ovulation leads to a decrease in Natural Progesterone.
Low Nat. Progesterone leads to relative Oestrogen Dominance
Symptoms/effects of Oestrogen Dominance:
Fat cells produce / store oestrogen: weight gain
Sodium/Potassium ratio unbalanced: water retention and bloating
Loss of Magnesium which is essential for Potassium uptake
High blood pressure because of high Insulin level, no Magnesium
Reduction of Oxygen amount in cells
Interference with Thyroid hormnes (ie.Insulin, etc )means: low metabolic rate, low energy, cold intolerance, weight gain
2) Excessively high Aldosterone levels, low Nat. Progesterone: causes excessive loss of urnary Potassium.
3) High Oestrogen levels: elevated Copper levels/Copper Toxicity
4) Already stressed system completely going out of balance in Salt/Potassium ratio
The amount of Aldosterone secreted normally is a direct function of the Serum Potassium. Potassium induces Aldosterone/Cortisol biosyntesis. Potassium should be strongly regulated at all Sodium intakes by Aldosterone when supply of Potassium is adequate. The supply of Potassium when supplementing Levonorgestrel can not be adequate leading to: high Aldosterone, Cortisol, Potassium/Magnesium depletion. Testosterone production may increase as a result, leading to excessive facial/bodily hair growth, head hair loss: masculinalisation.
Diet today is high in Sodium, low in Potassium and Magnesium (highly processed foods, growth soil mineral depletion) and supplemented with Xeno-Oestrogens: Nutritional uptake can not possibly rebalance Pot/Magn deiciencies nor lower Insulin levels. Only a strict protein, complex carbohydrate diet could assist.
Symptoms of Potassium deficiency:
Blood pressure elevation
Heart palpitations, arrythmia
Decreased liver and kidney function
Oestrogen build up
Depression, panic attacks
Levonorgestrel supplementation can lead to all of the side effects (being symptoms of the final conditions stipulated here) above interrelatedly. The long term consequence of usage and following malfunctions and deficiencies are as follows:
Liver disease, tumours
Hormone related cancer (eg. breast)
The symptoms most women exhibit and experience on Levonorgestrel are warning signs of the above mentioned conditions.
Because the cause and effect pathway of the conditions varies in time length and intensity of onset, initial physical constituency of women when starting on Levonorgestrel should be taken into account. The better the physical condition, the longer it might take for initial onset of symptoms, but the symptoms will arise and the conditions will follow.
Most doctors do not seem to be aware of the causal symptoms arising from the longterm use of Levonorgestrel and are therefore incapable of a diagnosis.
Because the symptoms vary greatly, depending on the gravity of the effects of levenorgestrel and their severity in onset, they appear to be non-related and difficult to track.
Levonorgestrel is marketed as safe, especially cost-effective, and good for long-term usage (5 year iud)device. What constitutes the danger is the long term supplementation of levonorgestrel, not necessarily the short-term usage, hence a five year period pescription is irresponsible, to say the least. The manifestation of symptoms and disease is longterm and as varied as the women using it are. Obviously not all symptoms and consequences have been followed in the cause-effect pathway in this text, but the featured ones sum the main complaints of the women seeking help in Mirena forums up.
I hope the above has shown, that all different symptoms arising under Levonorgestrel usage as 5 year IUD do all have a singular cause, should be identifiable by a doctor and have different times of onset and severity depending on the individual's physical constitution, the nutritional habits as well as the amount of exercise of the woman does at the onset and during the taking of Levonorgestrel . Please do not let doctors tell you that your problems stand in no relation to the IUD. Rather tell your doctor to do their homework
Estrogen dominance is a term originally developed by Dr. John Lee, an extensive researcher of the relationships between estrogen and progesterone. The term estrogen dominance describes the condition that occurs in a woman's body when estrogen is the dominate hormone in relationship to its natural counter balance with progesterone. Many people are unaware that women can experience estrogen dominance even with deficient or normal levels of estrogen present in the body. Estrogen dominance in and of itself does not necessarily mean a condition of excessive estrogen. What it does mean is that estrogen is the dominate hormone in its relation to the level of progesterone in the body. So, the overall level of the body's estrogen can be at a normal level, or it can even be at a deficient level, however, if the level of progesterone is also deficient and at levels not sufficient to counterbalance the effects of estrogen, then there will exist the circumstance of estrogen dominance. Estrogen dominance can have a number of causes, especially considering the excessive estrogen (or “estrogen-like” chemical compounds) that are now present in our everyday environment. These include products and substances we're constantly exposed to such as pesticide residue, plastics, meat products, an even furniture. Symptoms of estrogen dominance make for a long list. They include, but are not limited to, the following:
Acceleration of the aging process
Allergies, including asthma, hives, rashes, sinus congestion
Autoimmune disorders such as lupus erythematosis and thyroiditis, and possibly Sjoegren's disease
Cold hands and feet as a symptom of thyroid dysfunction
Decreased sex drive
Depression with anxiety or agitation
Early onset of menstruation
Endometrial (uterine) cancer
Fat gain, especially around the abdomen, hips and thighs
Increased blood clotting (increasing risk of strokes)
Irregular menstrual periods
Premenopausal bone loss
Thyroid dysfunction mimicking hypothyroidism
Water retention, bloating
These were the findings that were found as a result of Dr. Lee's research. For more information on his findings, visit http://www.johnleemd.com/
The findings of Dr. Lee's research go hand in hand with the numerous adverse side effects and reactions that women have reported having as a result of the Mirena, which is thought to be responsible for causing estrogen dominance. Here are just a few of the many side effects women have reported having:
Respiratory Problems(bronchitis, mono, athsma, etc.)
Pain in fingers, hands, arms, legs, etc.
Tingling and Vibration in various parts of the body
Heart Palpitations/Rapid Heartrate
I started to search for the answers when I developed the numbness on the right side of my body (it travelled from the leg, to the arm and then to the right side of my face),with constant headaches and brain fog, all within the first 1.5 month after the insertion. It was a very scary experience. I am otherwise healthy and athletic person, never experienced anything like this before.
I found the website above and took an extra dose of POTASSIUM and MAGNESIUM (on top of my daily multi-vitamin)and my symptoms dissapeared almost instantly.
Hope these findings will be of some help to many womens!
I am in shock at one of the side effects described by one of the women using the Mirena coil. I had the coil inserted 3 years ago after having my 2nd baby four years ago. I accidentally removed it while removing a tampon (I was never told not to use a tampon). While on the coil, i had experienced just about every symptom described in various websites. Terrible back pain (which i tolerated because i have always had back pain for the last 20 years) which was noticeably worse than before, extreme generalized body fatigue always in the mornings, an inability to engage in any form of exercise because of the extreme tiredness and joint pains all over. Unfortunately for me, i felt so much worse removing it most especially with the dysmenorrhoea.
What i find most frightening is what i just read about another person on this forum who has experienced a mysterious numbness on one side of the body.
I had the mirena coil replaced exactly one year ago and 4 months after symptoms which i could not tell if they were worse or just a bit better than when i did not have the coil, i woke up one morning to find the left side of my body completely numb. The only reason why i knew it was not the onset of a stroke was because i could talk and knew i was in no way hypertensive. It also helped that i am a Medical Doctor and felt that this was something i could not readily explain. I was rushed to the hospital and after a CT scan and a Skull x-ray was told i had a kind of arthritis of the bones in my neck (C6/C7) and i had to wear a collar for 2 months afterwards with physiotherapy to regain normal movement on the left side of my body.
With all the posts on the Mirena, my concern has been the fear of the effects of removing it which i am planning to do within the next one month. I will definitely start the Potassium, Magnesium, Calcium combination.
NB: I have put on 10kg since the 2nd insertion, its mainly abdominal and i always look pregnant and nothing seems to be working with a change in my diet since it is so painful to exercise.
I am so glad, i have found some research which i completely understand whether its backed by some scientific research or not because the explanation is plain enough to me especially the link with insulin.
Thank you so much for this information, i'll be sure to spread it as i know so many women suffering silently with the supposedly next best contraceptive in the market.
Mother of 4, thanks for all of this information.
I am 46 and had my second Mirena put in a few years ago. The past year and a half I am a hot mess. All of a sudden allergic to everything I put in my mouth, from soy, dairy, even the products in my milk alternatives. The last month High histamine foods are the newest trigger of bloating, fatigue, rosacea, facial swelling etc. My gut tells me that it is related to the Mirena. I honestly enjoyed not having a period and I believe the hormone has helped with the pms that accompanied the periods, but now I believe I am paying a price. My obstacle is how to safely detox off the thing. My doctor just gives me the deer in the head light look because they really don't know anything about it. When I had the first one removed I was in the hospital with a terrible migraine the following day (and I don't get headaches). Maybe a naturopath may be best.
Thanks again for the info!