If one believes the biofilm theory, then it makes sense to take a biofilm disrupting enzyme product like ProTherea Interfase or Kirkman Biofilm defense. Theoretically, these products will make it much easier for antifungals to kill hard to reach Candida hidden away in biofilm. Anyone had any experience with these products?
It makes sense but what concern me is I have read candida albicans biofilm matrix is made of different substances than the bacterial biofilms. I am not sure if there are mixed biofilms (bacterial and fungal) where the same disrupters can work. As far as I know, Cis 2- Decenoic Acid has shown to disrupts candida albicans matrix. There are some enzymes that also have activity disrupting fungal biofilms ( germ tube colonies ) I have saved a lot of this information in my computer that I need to review again. It may be the biofilms that don't allow the antifungals reach the fungus cells... I don't know if you can remember it because we have spoken about it in the past but cis-2-decenoic acid is a fatty acid probably very similar to undecenoic/undecylenic acid. So, it could means why SF-722 is thought to revert the fungal form of candida. Cis-2-decenoic acid is found in Royal Jelly. http://jb.asm.org/cgi/content/short/191/5/1393
I have done USMANS protocol. it didn't noticeabley change my symptoms. I think I will do another round of it again soon though now that i'm more strict on the diet and will be doing prescription antifungals.
A nice side effect which I was not expecting is the EDTA in teh protocol reduced my 1.6cm stone into 4 smaller pieces. The urologisst was recommending surgery with a stent.
I've been using serrapeptase to break up candida biofilm for about 4 months now, and I can definitely tell it is helping in my battle. The only antifungal I use is extra virg coconut oil, and the serrapeptase seems to amplify the oil, causing a more significant herx than taking the oil alone. It's a delicate balance to avoid over-doing it and feeling like hell from too much toxic release.
My candida goes back about 20 years. I think for those who have suffered with this problem for any extended length of time, it is important to take a biofilm dissolving enzyme. I've been actively fighting candida for about 8 years now (yep it took me 12 years to identify what my problem was... i love western medicine), and Im convinced that I could never fully recover because I had long-established candida hiding under biofilm "fortresses" that would hide from antifungals and my immune system, and then re-emerge when it's safe.
So far I have not noticed any candida resistance to either serrapeptase or vco. I figure it will take about 16-20 months to really regain my health since I've had the problem so long.
On a side not, I'm also working on re-balancing my minerals. Zinc, boron, iodine, manganese and molybdenum have been especially helpful. I was definitely copper-toxic, supplementing zinc has helped me immeasurably with that.
I also take Primal Defense Ultra probiotics (currently 3 per day, 15 billion cells). They are super potent but have really helped me alot.
I have no experience with the particular biofilm dissolving enzymes you mention, but the serrapeptase is working for me, so I plan to stick with that for now.
As a side note, I have lost about 6 pounds since starting the serrapeptase (I'm still about 10 pounds over my ideal body weight). Diet has remained constant (very strict candida diet) and my exercise has actually dropped off in that period. I honestly believe the serrapeptase has helped facilitate the weight loss, by removing some candida colonies and reducing structured waste which the body naturally accumulates as we get older (especially for those raised on western diets and antibiotics.. yum).
I've taken biofilm enzymes before ... I think Ive done 2 rounds about a month long each. I believe it is very important ... the medical literature indicates that most microorganisms live within biofilm and today I'm reading that a big part of why antifungals are nto effective is because of teh biofilm.
I'm wondering how you came to choose serripepidase ? I believe it breaks down fibrin.
Dr. Anju Usman discusses biofilsm in her autism talks. I've listened to them in the past but she seems to concentrate on bacteria, not fungus. I'm about to lissten to the spring 2010 talk ... I'll report anything helpful.
I did alot of reading on serrapeptase indicating that it could effectively digest candida biofilm before I started supplementing. I also liked that it was indicated for reduction of allergies and inflammation. I've had severe fall mold allergies for as long as I could remember, but from the moment I started taking serrapeptase in september of 2010, my allergies have been gone. Not a single sinus headache or pain in a part of the year when Im usually pumping myself with benadryl and wanting to die. I honestly couldnt believe how effective it is for allergies.
Anyway, sorry to get off topic a little. Yes, serrapeptase is a fibrinolytic enzyme (which could have implications for helping with problems like cancer also). Other biofilm busting enzymes like nattokinase and lumbrokinase are on my list to try (as well as mixtures like interfase), if the serrapeptase does not effectively clear my candida completely. But judging from my progress the last 4 months, I really think it's going to do the job (along with diet, vco and probiotics).
Not to be too gross, but since starting the serra I have noticed what I believe to be the dissolved biofilm showing up in my stool. It appears as a greasy film that spreads across the surface of the water. The film is proportional to the amount of serra I ingest and the severity of the resulting herx.
Btw, from my experience, enteric coating is not needed for serrapeptase to work, contrary to what some vendor websites report. I noticed effectiveness with non-encapsulated powder in doses as low as 10,000 serratio units. I have slowly increased my dose to about 30,000 units per day over the last 4 months, and it is clearly working for me without enteric coating. Enteric coatings are usually HPMCP, which is a toxic pthalate and not something anyone should ingest daily anyway.