Praziquantel kills all species of flukes in the blood, liver, GI tract, pancreas, & lungs.
It's taken together with Albendazole, which systemically kills leftover eggs, larva, & cysts & those disseminated or scattered throughout the body.
These drugs have synergistic action when taken together, versus taking each drug as a separate treatment, & result in higher cure rates.
For hyperinfection cases, several cycles of drug treatment may be required. Before starting a new cycle, rest the liver for 7 days.
Take 1dose* (25mg/kg), tablets or gelcaps**, 3 times daily, evenly spaced 6 hrs apart, for 3 days. Take each dose with 8oz water. Take AM/PM doses with Albendazole (see below). Rest liver for 7 days. Repeat dosage for 3 days. See Drug Schedule below.
*To calculate dosage, see Dosage Examplebelow
**Instead of tablets, you can pour Praziquantel powder into empty gelcaps. 00-size gelcaps hold 600mg. Use a Q-tip to firmly press down powder into both parts of gelcap.
Convert your body weight from pounds (lbs) to kilograms (kg), using the Curezone "Convert Weights Easily" Calculator (scroll to middle of page): http://curezone.com/conversions.asp.
Each Dose = 25mg/kg
Your weight = 160lb = 72.57kg (rounded 73kg)
Tablet = 600mg
Tab Dosage = 25mg x 73kg = 1,825mg (1,800mg rounded)
Tab Dosage = 1,800mg divided by 600 = 3 tabs
Tabs 1 Day = 3 tabs x 3 times = 9 tabs
Tabs 3 Days = 9 tabs x 3 days = 27 tabs
Tabs 6 Days = 9 tabs x 6 days = 54 tabs
Gelcap (00 size) = 600mg
Powder Dosage = 25mg x 73kg = 1,825mg (1,800mg rounded)
Gelcap Dosage = 1,800mg divided by 600 = 3 gelcaps
Gelcaps 1 Day = 3 gelcaps x 3 times = 9 gelcaps (5,400mg)
Gelcaps 3 Days = 9 gelcaps x 3 days = 27 gelcaps (16,200mg)
Gelcaps 6 Days = 9 gelcaps x 6 days = 54 gelcaps (32,400mg)
Take 1 dose,* 400mg tablet or 3.5ml suspension, twice daily, AM/PM, evenly spaced 12 hrs apart, for 14 days. On Days 1-3 & 11-13, take with AM/PM doses of Praziquantel (see above). Take each dose with 8oz water & 40g fat.** See Drug Schedule below.
Note: Taken for longer than 2 weeks without a 1-week rest break may result in temporary hair loss (Alopecia), liver impairment, or parasite drug-resistance.
Albendazole is poorly absorbed in the gut, so you must chew tablet very well. Or use a pill splitter box, crush tablet into smithereens, & sprinkle on soft food.
*Instead of tablets, you can take Valbazen (Albendazole) Oral Suspension for Cattle & Sheep. It contains 11.36% or 113.6mg/ml of Albendazole. Use an oral syringe to measure 3.5ml, which equals a 400mg tablet. Mix into 8oz beverage or soft food to mask the yucky taste. May add sugar or other sweetener.
**You must consume 40g fat with each dose of Albendazole (e.g., grilled cheese sandwich, ice cream, cheese pizza, cheesecake, buttered popcorn, peanut butter, cheese, cottage cheese, whipped cream, sour cream, melted real butter, or salad dressing over food, etc). Check food labels for fat gram content. Fat acts as a carrier & increases absorption & plasma concentration. If you omit this step, you'll just flush $ & meds down the drain!
Ordering Valbazen (Albendazole) Oral Suspension for Cattle & Sheep:E-Bay, online veterinarian suppliers, & online or local livestock feed & supply stores. For brands available in other countries, search at google.com.
Flukes (Trematodes) are leaf-shaped flat worms. Their life cycle begins when larva are released into freshwater by infected snails.
The free-swimming larva can penetrate the skin of human hosts. They also encyst in various edible vegetation, undercooked water plants (i.e., watercress), shellfish, crustaceans, & fish. They're found in beef, chicken, pork, & unwashed vegetables. Also carried by dogs, cats, & other fish-eating animals.
Flukes are one of the hardest parasites to kill. They lay thousands of eggs daily & form large colonies in the blood, lungs, pancreas, liver, & GI tract. Adults live for about one year. Encysted flukes can live in the human body for 10-20 years.
Often there are no symptoms until a hyperinfection stage is reached or they're passed in the stool. For specific symptoms of blood, lung, liver, pancreas, & intestinal flukes, review References below.
When passed in the stool, flukes appear as curled or rolled-up tomato skins, brown sticks, tan or brown leaf-shapes, yellow flakes, or brown pods pointed on one end. The stool is usually soft or loosely formed & a tan or yellowish color.
Young intestinal & liver flukes are small, flat, white worms, wide on one end & narrow on the other. Adults range in shades of pink, red, & almost black. When passed after taking parasite meds, they appear as dark or blackish blobs.
For severe infections, several cycles of drug treatment may be required.
For symptoms, life cycles, & pictures of flukes, see references below.
Carefully research all pros & cons of drug treatment based on your overall health condition, medical history, & other meds you're taking (see above drug monographs & references).
Before starting any drug treatment, recommend medical diagnosis & lab testing to confirm the type of parasitic infection you have so that appropriate meds are used for treatment.
But brace yourself for bad news. Even when you take in whole worms or specimens for lab tests, results are usually negative!#? (lol) This occurs when specific parasite tests (there are many to choose from) aren't ordered by your doctor. This also applies to blood tests.
Stool tests are also unreliable. The sample you collect may not contain any worms, eggs, or larva because they're not shed everyday. Or the lab takes a small smear that doesn't contain anything to test although other areas of the sample contain parasites. Or specific parasite tests aren't ordered.
Brace yourself for more bad news. The mantra of most doctors is that all parasite infections only occur in 3rd world countries or poor, dirty, uneducated, lower-class folks!#? They usually diagnose patients w/"Delusional Parasitosis" & prescribe anti-psychotic drugs as a cure, which, of course, is a big dose of "BS". (lol)
So be sure to take tranquilizers or blood pressure meds before your office visit so you don't go BESERK when you're told you're CRAZY!?#. (hee hee) Or try my tips for doctor appointments:http://curezone.com/forums/fm.asp?i=1611820.
Good luck in your parasite battles!
Keep us posted on your progress ~ feedback helps everyone on the forum!
My Motto: Aim high, shoot low, & use big guns!
And as the African warrior Shaka Zulu said: Never leave an enemy behind. (lol)
Cheers ~~ ICU
P.S. If you have any questions, take 2 aspirin & call me in the morning. My number is 1-800-WHO-CARES? Just kidding! ~ Meow Meow
"prazi also, is not good, since its carcinogenic, "
if this were known why are not the big books on tropical medicine saying anything about this?? some very recent research?
Or are you misunderstanding? People living in endemic areas of liver flukes and/or schisto are likely to use prazi from time to time, but they will still often get re-infected in endemic area (if not begin very careful, well depends on type of flukes there). It is well known from research that several flukes dramatically increase risk of several types of cancer (depending of type of flukes). Many people in endemic areas that have used prazi will therefore still get cancer, but where is the studies telling this is because the medicine, if no such study exist, then it is much more likely to think this is because they get re-infected, or treated too late (when flukes already have caused cancer).
There is many studies showing many flukes dramatically increase risk of cancer. But where are the studies showing praziquentel increase risk of cancer? If such studies exist, yes then they should naturally be taken very seriously, but I would like to see them
I would like more information on the drug and where / how to obtain it? Are any of the three available without a script? Been doing high doses of anti parasite herbs for 5 mos. and ready to get a scr1pt if necessary...
Praziquantel (Biltricide) kills adult flukes in the liver, GI tract, blood, pancreas, & lungs.
Albendazole (Albenza) is a systemic drug. It kills leftover fluke eggs, larva, & cysts & those scattered or disseminated throughout the body.
There are drug-resistant strains of Fasciola Hepatica (Sheep Liver Fluke), Fasciola Magna (Deer Liver Fluke), & Fasciola Gigantica overseas where Praziquantel has limited effectiveness (60% cure rate).
The drug Triclabendazole (Egaten) is used for those flukes in endemic countries (Egypt, N. Africa, Europe, SE Asia, etc.) (85% cure rate).
The veterinarian liquid suspension of Triclabendazole, Fasinex, is used overseas for livestock infected with drug-resistant strains. It's also used for humans when Triclabendazole or Egaten tabs are unavailable.
In trials & studies, other drugs had varying results but less effective cure rates: Nitazoxanide, Myrrh (Mirazid), Clorsulon, Bithionol, & Artesunate.
Fasciola hepatica (Sheep Liver Fluke) (left)
& Fasciola magna (Deer Liver Fluke) (right)
A-Fasciola Gigantica & B-Fasciola Hepatica
Triclabendazole (Egaten & Fasinex) are banned for sale & shipment to the US & Canada. They can be obtained through bootleg sources, but the cost is very expensive.
For rare cases of these flukes in the US, a doctor can request Triclabendazole (Egaten) on a special-needs basis from Novartis or Bithionol (Lorothidol or Bitin) from the CDC.
Before obtaining Tricla/Egaten/Fasinex for self-treatment, suggest lab testing to confirm infection w/these flukes. This step might save you a lot of money in the long run!
Am J Trop Med Hyg. 2006 Aug;75(2):287-91.
Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model.
Keiser J, El Ela NA, El Komy E, El Lakkany N, Diab T, Chollet J, Utzinger J, Barakat R.
Swiss Tropical Institute, Basel, Switzerland.
Some have claimed that triclabendazole, a safe and efficacious drug for the treatment of fascioliasis, also exhibits antischistosomal properties, but results are conflicting. We assessed the effect of triclabendazole and its two main metabolites against two different strains of Schistosoma mansoni harbored in mice. Low worm burden reductions (18.6-35.9%) were observed in mice infected with an Egyptian strain of S. mansoni and treated with a single dose of 120 mg/kg 3 days before infection or single/double doses of 120-200 mg/kg 7 weeks after infection. Triclabendazole failed to significantly reduce hepatic and intestinal tissue egg loads, and eggs of all developmental stages were observed. Administration of 400 mg/kg of either triclabendazole, triclabendazole sulphone, or triclabendazole sulfphoxide to mice infected with a Liberian strain of S. mansoni resulted in worm burden reductions < 10%. In comparison, high worm burden reductions (82-100%) were observed in S. mansoni-infected mice treated with single oral doses of 400, 500, or 500 mg/kg twice a day praziquantel, regardless of the S. mansoni strain. We conclude that triclabendazole and its main metabolites display weak and inconsistent schistosomicidal activities.
First of all I would like to THANK you for sharing your knowledge, it's been quite the uphill battle (to say the least) but discovering the liver flukes a ways back has given myself a place to start and having people share their insight is and has been a major BLESSING.
My question; my liver seems to be quite a mess at this time. While taking the liver fluke protocol, would the coffee enema
(as opposed to the Fleet enema recommended) be considered a
problem, in your opinion. Major sluggish liver and feeling it's working overtime (even juicing and eating light)at this time, have about 10 more days for regime.
hi dee, i don't use enemas. i have them all in the tissue surrounding my anus and rectum-i dont go there. but you do need to take milk thistle for your live health-cause the prazi wrenches it. i take it as a supplement when i'm not on my prazi & quin hao treatment. i begin my 14 day treatment starting on the full moon of every month. on 3 days, off 7 back on for 3 more. i do my quin hao every sunday.
I have thankfully been lurking the pages of Curezone for the past 2 years. During that time I have done several Colon Cleanses as well as parasite cleanses to alleviate my symptoms, the worst being chronic fatigue.
I first had a hair analysis done which determined I was high in heavy metals especially copper (in the 100 percentile). So at first I was hopeful that a few Colon Cleanses and heavy metal detoxes would do the trick, because of course I didn't have parasites. Ha!
Upon doing my colon cleanses I released hundreds of intestinal flukes. I tried heavy doses of herbal remedies, but was still very sick. After a few attempts with the herbs I switch to just Albendazole which also did very little.
It wasn't until I did ICU's full protocol of Prazi and Albendazole together was I able to see some huge progress! (and eating a grapefruit seemed to amp it up) I have how now identified 4 different types of flukes. I am feeling much better but still not 100%. How do you know when all the flukes have been eliminated?
I thought I was done after the 2nd round, but then I took about 6 tablespoons of coconut oil (for diet reasons) and 2 days later found a HUGE 2 inch fluke! (I felt super sick after the coconut oil, but I know now it was die-off) Could this have been oil pulling out the remaining flukes left behind?
I wrote you a while back asking for more details about this protocol. I am 2-1/2 days from completing the protocol. I have a microscope and a look at my blood this morning revealed that there are still flukes in there. They do seem diminished in number and smaller than usual, but I am not 100% sure about this and to my dismay, they are still there. I think that if the protocol worked, they should be hard to find at this point.
So, now, I am looking at doing the whole nasty process again and am wondering if that will even get them. So, the reason I am writing is to ask if blood flukes are that hard to get rid of or do I need to do something else? I looked a bit this morning at other meds for flukes, but it seems I can't get most of them easily. (I am now really into vet meds, which come cheap, with no nasty additives, and are just the pure stuff.)
Do you think a second round of this very much not fun and seemingly toxic treatment will get the last ones? What tests did you use to determine if you were cured? I am using a blood smear with wrights/giemsa stain.
There are no real symptoms from liver flukes that you would notice casually. (Except at the hyperinfection stage, when you will have all sorts of symptoms but very diffuse ones: fatigue, lethargy, brain fog, water-swollen abdomen from liver damage (a pseudo-beer-belly, basically), elevated bilirubin levels, etc.)
I had all of the above symptoms when mine got to the hyperinfection stage, and I had no idea it was liver flukes (I had no idea what a liver fluke was). Until one obese fasciola hepatica or gigantica got stuck in a gallbladder duct, giving me a severe gallbladder attack that required a 911 call, an ambulance ride to the emergency room, and three days in the hospital while the puzzled emergency-gallbladder-surgery team that had been assembled to remove my gallbladder looked in vain for any sign of Gallstones in my gallbladder.
( Gallstones are the usual cause in the West of gallbladder attack, i.e., biliary duct obstruction. I have no gallstones; in my case, it was presumably a big fat fluke.)
Anyway, I was very lucky to have an honest surgeon in charge of the team who did not whack out my gallbladder (the malpractice-defensively-safe thing for her to do), but instead told me she had no idea what had caused my gallbladder attack but since ultrasounds and CT scan had shown no signs of gallstones, and I had passed whatever was jammed in my bile duct, and 3 days of IV doxycillin had cured the resulting inflammation/infection, she was releasing me with my gallbladder intact.
And a medical mystery that it took me about ten minutes to half-solve on Google, which told me there is of course another cause of thickened gallbladder wall, inflamed/infected gallbladder, and bile-duct obstruction besides gallstones -- liver flukes.
The other half of the mystery was solved when three days later I passed a bolus of dead flukes. Something they did in the hospital killed them -- the scans or the doxy, presumably, as that's all that could have. Since some were fasciola, that is, big honkers, I sorta saw them in my stool just looking at it (after blood and mucus on the tp alerted me I might want to take a look in the bowl). I went to the CDC site, found their Parasite Image Library, matched my critters to the pics of fasciola and c.sinensis, and had my answer -- I had liver flukes. I Googled the treatment protocol, which brought me here and also to various public-health sites, which have variants. I used the fluke treatment protocol here while waiting 2 weeks for an appointment with an ID doc, because I wanted the things out as soon as possible, given their tendency to land me in the ER & then the hospital.
Which was a good idea. The protocol here works, whereas the Infectious Disease doc, with his lucrative travel medicine practice, prestigious hospital affiliations, and MD from Columbia, told me the whole specimen I brought in looked like a piece of zucchini (my telling him I don't eat zucchini made no impact) and diagnosed me officially with constipation and unofficially but obviously with delusional parasitosis. I begged for a stool test (not yet knowing about the notorious unreliability of stool tests), which request he very reluctantly granted, and which of course came back negative anyway, even though I had put quite a few of the most obvious dead flukes and a lot of ova in both containers, along with some stool.
Lung flukes are also asymptomatic until they get really bad. Or, you scare them "awake" by taking prazi for your liver flukes. Either way it starts, the symptom is that you begin to have to compulsively spit, because the back of your throat tickles. And you spit up really thick, bubbly, mucus-y spit that's tinged pale brown (that's blood, I later read). The latter happened to me when I was doing the prazi for my c. sinenses, & went on for two days and then stopped. I think the prazi got most of them. And I think I have finished off the rest now -- I rested a while and then ordered triclabenzadole for the fasciola from Dr. Chieu and that seemed to do for most of the rest; after the tricla course, there was only the faintest tinge of pale brown when I spat after brushing my teeth. A final course of prazi a bit later has cleared that up, and my spit is clear again.
Now for the tapeworms, and then the hookworms. (Sigh.)
It shouldn't -- not as much as liver flukes do, anyway.
If you go back and read through ICU's whole fluke protocol, the first message in this thread, you'll see that he says to take a break after 2 weeks of albenzadole because that is getting to the edge of how long it's safe to take that continuously.
Prazi is a very very safe drug, from what I have read. Assuming you follow the directions. Even when it's given to parasite-infested, malnourished-from-birth third-world children and old people, I've never read of any side effects besides a little gastrointestinal upset and lethargy, and some researchers have made a convincing case that that is die-off, not actually the drug per se. One paper noted there's never been a reported incident of side effects from praziquantel serious enough to require medical intervention. Which is impressive considering it's given en masse to people sickly to begin with. (In another study, I noticed, the placebo group had slightly more side effects than the ones actually given praziquantel.)
Albendazole seems to have more toxic effects if taken for more than two weeks (at recommended dosage) without the rest break for the liver.
I am not a doctor, though, nor play one on TV. I would heartily recommend asking one, except for the difficulty we all seem to have in finding a doctor to ask. Hence my own reliance on papers published by the public-health research community, which knows far more about parasites but is not legally allowed to practice medicine without that M.D., at least not here in the U.S. (And how the AMA keeps up that monopoly is a superb question. Why DO we need permission slips from incompetent doctors who can't figure out we need them, to buy FDA-approved, safe and effective medications? When we have no choice but to diagnose ourselves because doctors can't, but it is not really that hard, assuming motivation and a willingness to look at and listen to the evidence and some really basic research skills, so we can? But that is an aside.)
All I can say is I feel much the better for killing my liver flukes off. And my gallbladder, at least, was demonstrably damaged by them -- they could see that much in the hospital -- and so was my liver, given how much edema I had that is disappearing with amazing rapidity. So killing the liver flukes with prazi and tricla has done my hepatic system a world of good.
But I am not qualified to say what it will do for you. These treatments should really be undertaken undera doctor's supervision. Pity there are no doctors up to the task except in Asia, apparently.