We really need your tin foil hat helping us understand this better.
My question is this--
If a person that is chronically ill (lyme's)has both high levels of nitric oxide..and high levels of ammonia...
and the process of breaking down ammonia into urea is with an ornithine enyzme...but ornithine is a nitric oxide producer...should a person with both high ammonia AND high nitric oxide use ornithine (further increasing nitric oxide productions?) Don't mean to get you confused with my confusing question :(
I know high levels of ammonia are an indication of liver and kidneys not being able to process ammonia out, and can lead to a serious condition (including coma and death). Many things can be the cause of ammonia (including Lyme's), this one says intensive exercise..
>>>>Ammonia itself is a by-product of intensive exercise, and without the urea cycle the body would rapidly become polluted. It is a very toxic product, and causes the death of thousands of people each year. This is generally in people who suffer liver and kidney disease, and the ammonia can not be broken down and excreted.
Your brain cells are particularly sensitive to ammonia, and as levels increase the effect progressively ranges from drowsiness thru tremors to coma and eventual death. Any condition, therefore, that reduces the body's capability of metabolizing ammonia is potentially very serious, and any supplement that can help prevent this is valuable.>>>>
David Jernigan says:
>>>>The Bb in joints and musculoskeletal tissues may be creating symptoms due to the conversion of NH3 to nitric oxide (NO), which is well documented as causing multiple pathological processes, including sepsis, hyperactive inflammatory processes, and joint pain. Direct resonance testing has revealed that the liver and heart are often testing positive to accumulations of NH3, which is not being converted into urea or nitric oxide.>>>>>
Nitric oxide is not a bad thing, normally, but from what I'm understanding, the immune system causes increased nitric oxide against different pathogens. I was just reading where people that have malaria, have also been found to have high nitric oxide levels too.
>>>Macrophages, certain cells of the immune system, produce nitric oxide in order to kill invading bacteria. In this case, the nitric oxide synthase is inducible NOS.
Under certain conditions, this can backfire: Fulminant infection (sepsis) causes excess production of nitric oxide by macrophages, leading to vasodilatation (widening of blood vessels), probably one of the main causes of hypotension (low blood pressure) in sepsis. The inducible isoform of nitric oxide synthase is expressed and produces cytotoxic levels of nitric oxide.>>>>
This guy is saying the same thing, that common pathogens/toxins are found in CFS, Fibromyalgia, and one thing that is found in them both, is elevated levels of Nitric Oxide.
>>>We have, here, 17 diverse stressors implicated in initiating these illnesses, leading one to ask, how they may do so? What I have argued, in my book (1) and elsewhere (2-10), is that each of these can act to increase nitric oxide levels. Each is reported to increase the levels of nitric oxide, or in three cases where that has not been studied, to stimulate a process which is itself known to increase nitric oxide. This is a striking common response and leads to the question about how nitric oxide increases might lead to chronic illness? My answer to that question is that nitric oxide, acting primarily through its oxidant product peroxynitrite, initiates a biochemical vicious cycle that is responsible, in turn, for the chronic illness. We have, then, an initial cause of illness (short-term stressor or stressors) acting to start this vicious cycle, with the cycle responsible for causing the chronic phase of illness. We are now calling the cycle the NO/ONOO- cycle after the structures of nitric oxide (NO) and peroxynitrite (ONOO-) but pronounced no, oh no! The cycle mechanism is outlined in Figure 1:>>>
Table 1. Illness: Stressors Implicated in Initiation of Illness
Chronic fatigue syndrome
Viral infection, bacterial infection, organophosphorus pesticide exposure, carbon monoxide exposure, ciguatoxin poisoning, physical trauma, severe psychological stress, toxoplasmosis (protozoan) infection, ionizing radiation exposure
Multiple chemical sensitivity
Volatile organic solvent exposure, organophosphorus/carbamate pesticide exposure, organochlorine pesticide exposure, pyrethroid exposure, mercury exposure, carbon monoxide exposure, hydrogen sulfide exposure
Physical trauma (particularly head and neck trauma), viral infection, bacterial infection, severe psychological stress, pre-existing autoimmune disease
Post-traumatic stress disorder
Severe psychological stress, physical (head) trauma