With your semantics, yes "viral elimination" is possible. However, HIV does not live as a virus in the body until just before it breaks from the cell and is released. HIV lives as an integrated part of your DNA in infected cells.
If ozone works (not saying it does or does not), and if you can get it into the cell, it can kill the viruses that the cell is making. This does NOT mean you are killing the HIV though, because the Ozone will not destroy the cell's DNA (which is where the HIV lives). This is the problem and beauty with HIV and other RT parasites. They can integrate themselves with a host, without killing the host for long periods of time, leading to better chances of infecting another host and survival of the virus. And since they are integrated with the host DNA, the only way of killing the virus is to kill the host as well. In evolutionary terms, HIV is one of the best viruses nature can create, which is what makes it so problematic.
Now, many things can be done to keep your viral load low and your disease under control, but HIV can never be "cured". This is not to be all doom and gloom, you can live an almost normal life with HIV if you treat it correctly. However, the ONLY way to live without HIV is to never have gotten it in the first place.
Let me just state that I am fully aware that HIV is an endogenous retrovirus that integrates its DNA into the germ line cells which then is passed vertically from parent to offspring entwined with our very own DNA.
However think of this - does the HIV DNA encoding itself onto ours really matter? Let me explain:
BTW up to 10% of all human DNA consists of retroviral code from endogenous retroviruses.
A child born to HIV+ parents who luckily does not get any infective virus particles in its body during gestation or during child birth and that tests HIV negative is considered by all doctors of the world of every single government to be ok even though it has HIV DNA somewhere embedded with the childs own DNA. This HIV DNA is doing no harm and is not producing new viruses.
It is the actuall viruses that replicate in our various immune cells that cause the immune cell depletion not the DNA footprint they leave with our own.
Destroy all the virus particles in the whole body and you are effectively cured, yes you will have some HIV DNA as part of yours but it doesn't mean that now new copies of viruses are being manufactured in your immune cells any longer.
Let me first of all say that I am glad someone who talks about this subject actually knows something about what they are talking about. Too many people try to discuss a topic without any good background or information.
You mentioned two good points:
1. Parent vs. Child
First, one needs to realize how important the placental barrier is: most bacteria and viruses do NOT cross it. As long as you can keep your viral load low, the fetus has a 95% chance of NOT being exposed to the virus at all. This means not only do they not have viral particles being created, they also do NOT have ANY HIV in their DNA.
Second, Germ cells (reproductive cells) are also rather segregated from the rest of the body. Unless you have had HIV your whole life, or have a high viral load, your germ cells will not have the HIV encoding in their DNA. This means you can have a HIV free child (free from the HIV DNA, not just the virus). HIV tends to target immune cells first, blood cells second, and cells outside the bloodstream last. If you can keep your viral load low, the HIV may never leave the bloodsteam and enter the germ cells.
When a child is tested and concidered "free" from the HIV virus, its because they usually are completely free of it. There is NO HIV in the DNA. This does not mean that HIV is harmless.
2. We have many retroviruses in our DNA.
You are absolutely right, but most of those DNA fragments do not replicate on their own, they are just random DNA. Most of those that do self-replicate, have no other function. HIV is completely different from these other retroviral fragments because it has other functions. HIV aggressively replicates, takes over the infected cell, produces more HIV, and destroys the cell as the new HIV are released. Since HIV preferrential targets immune cells, this is what causes the AIDS syndrome of an immunocompromised patient. None of the other DNA viral fragments do this. One cannot claim that since these other viral fragments are dormant, that HIV will ever be dormant either.
If you are infected with HIV, there is NO CURE. Cure being defined as "no more viral DNA or viral particles in the system". Again, I did mention that you can live a relatively normal life with HIV if you can keep your CD4 up and your viral load down.
One cannot call a lack of symptoms or a low viral load to be a cure. Because if the body is weakened again, or you fall off your treatments the HIV will come back. The HIV does not come back because you are reinfected, it comes back because the HIV you were already infected with are allowed to gain control again.
The DNA footprint can never be removed, and as I said before, this is the reason HIV is so dangerous and such an evolutionarily perfect disease. The ONLY possible way to be HIV free is to never have been infected in the first place.
>The ONLY possible way to be HIV free is to never have been infected in the first >place.
A few things to keep in mind:
HIV infection CANNOT cause any diseases in man.
AIDS is not a disease.
HIV antibody testing is notoriously inaccurate having over 65 known causes for false positives. Therefore, the prevalence of HIV is not near as high as we have been led to believe. By the way, the confirmation test is an even less accurate antibody test. And viral load (PCR, polymerase chain reaction) is a joke. It cannot confirm the presence of a particular virus, nor viral activity as is being claimed.
>Let me first of all say that I am glad someone who talks about this subject >actually knows something about what they are talking about. Too many people try to >discuss a topic without any good background or information.
And you consider yourself some type of expert? I have yet to see you get much of anything right. A lot of assumptions, but that is about it.
Again, since you think of yourself as an AIDS expert then let's see you answer a few basic questions:
1. What is the primary reason for false positives in HIV antibody testing? I am asking about the principle that makes these tests so inaccurate. And yes, there is a medical term for it and it is very well known.
2. Why is AIDS not a disease?
3. Name at least 5 of the most common causes of AIDS.
4. Why is it impossible for HIV to cause AIDS under the ORIGINAL definition of AIDS that led the government to change the definition to fit the virus?
5. Why does AZT shorten the lives of people taking it?
We will start with this real simple and basic questions. Anyone that has studied AIDS for a while or even immunology should be able to answer these questions with no problem.
It has been many years since I took genetics (never my area of interest) in grad school, but I'll do my best to handle this one:
If HIV were an endogenous retrovirus, it would have infected germ cells (sperm or egg) by definition - HIV DNA would then be in the DNA of every nucleated somatic cell in the body (barring some mutation post-birth that somehow excised it), not just in a random cell here or there that could be difficult to find.
There is no good evidence that HIV is able to get into the germline in vivo under natural conditions. For example, there has yet to be an HIV+ baby born to an HIV+ father and an HIV- mother. One can't rule out that this may happen at some point in the future, but the chances seem pretty remote.
The reason why quiescent cells that have integrated HIV into their DNA are problematic is because they can be reactivated and the virus can start replicating again. This happens in T-cells that HIV has latently infected: so long as the cell is quiescent, there's little if any viral replication. As soon as the T-cell is activated (by, for example, a virus), replication can crank back up again (this is because HIV depends for replication on the same transcription factors that are necessary for T-cell activation). This is the reason why even therapies that remove every viral particle from the body do not actually represent a cure.
Hi! Sorry I just noticed this question (I wasn't ignoring you!)
Here's my quickie shot at an answer (one which I had to look up, because unlike the questions I usually respond to, I really didn't know!)
If there is a list somewhere of all the cells HIV has been shown to be able to replicate in (either in vitro or in vivo), Iíve never seen it.
The most important sites of HIV infection are indeed certain white blood cell types Ė CD4+ T-cells (which are not necessarily all T-helper cells; other T cells can and do express CD4 under certain circumstances), CD4+ macrophages, and dendritic cells.
Other cells have been shown to be able support HIV replication either in vivo or in vitro, but itís not always clear what importance this has to the natural course of HIV infection. In the lab, you can transfect HIV into many cell types, and under certain conditions, induce replication, but itís not always clear that this is indeed what happens under natural conditions of HIV infection.
HIV can damage even those cells that are not HIV-infected, and the fact that HIV can replicate in certain cell types does not necessarily mean that infection of/replication in these cell types are particularly important to disease pathogenesis.
Some cells that may, at least under certain circumstances, be able to support HIV replication (although perhaps only at low levels or under certain conditions) include: