I take 1,500 to 2,000 per day but never more than 500 mg at a time because it makes me a little anxious. I have no clue how much cortisol each pill contains or if it even works that way but I quit the isocorts and hydrocortisone about a month ago. I still do a hydrocortisone shot every few weeks at only 2.5mg, if that. I am feeling better on the B5, Vit. C, and B-Complex. I think the liver stuff is really helping Ladywear! It was $27 online. It's biotics and it's called ultravir-x. It takes around a month and can sometimes make you feel more tired but each week you should feel better and better if you think you have a sick liver. I am taking mine for a virus. I am also taking the orenda immune which is $60! I couldn't do the adrenal glandulars and cortisol, they made me feel like crap. I think slowly re-building them w/vitamins is working for me but I may have had to do the other things before to get to this point. I am very up and down, good days and bad days!