Albendazole, an Effective Single Dose, Broad Spectrum Anthelmintic Drug
Shivaji Ramalingam, B. Sinniah AND Uma Krishnan
Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Albendazole, a new anthelmintic drug was evaluated in Malaysia in 91 patients, with single or mixed infections of Ascaris, Trichuris, and hookworm. Albendazole was administered as a single dose of 400 mg, 600 mg, or 800 mg. The cure rate for Ascaris at all three doses was 100% at days 14 and 21 post-treatment; for hookworm it was 98.8%, 100% and 98%, respectively, at day 14 and 68.8%, 100% and 84%, respectively, at day 21; for Trichuris it was 31.2%, 57.1% and 42.3%, respectively, at day 14 and 27.3%, 60.9% and 48.0%, respectively, at day 21. The egg reduction rate at day 21 was 100% at all three doses for Ascaris, 94.5%, 100% and 96.1%, respectively, for hookworm; and 39.2%, 85.1% and 72.8%, respectively, for Trichuris. There were no side effects, and biochemical examination of blood and urine did not indicate any unfavourable changes. Based on this trial, the recommended dosage for Ascaris and hookworm is a 400 mg single dose, and for Trichuris is a 600 mg single dose. Albendazole appears to be more effective than other available anthelmintic drugs.
I think the article is reporting on using albendazole as a single dose for one day, and that's all. then follow up at 14 and 21 days to see how effective this one dose was.
the method they use to measure effectiveness is eggs in stool. I don't know this is the most reliable method to determine if infection is actually gone. considering I've had numerous tests like this, while teaming with parasites, and they always come back negative. according to them, I"m parasite free. so if they aren't catching it at all sometimes (often) then saying the egg rate was much reduced after using a drug...how does one know if it is truely reduced, or it's what happened to be caught (or not) in that sample on that day.
studies can sometimes appear to be making accurate conclusions, but all is not as it seems. the place to know how accurate results are is not in the title or conclusions. it's in the method. that's where you can see if the study is done in a way that supports what it claims.
yea, I agree. I was only meaning to say it's hard to know if a single dose of albendazole does what this study is saying. not that it wouldn't be worth trying....in proper dosing. but what is that? and what is the extent of all parasites in a certain case because this effects what drugs are used. and added to that, infections can be extensive. so treatment isn't so simple, and things can get worse too. I'm often more concerned about safety of treatment actually than if it would work or not.
i'm trying to figure out what's the most effective treatment for parasites (because i didnt find natural methods to be that effective). I passed by posts mentioning praziquantel Ivermectin and albendazole, please share your experience with me if you have any observations/advice, thank you - dominika