Megavitamin B-3 dosage in treatment of Arthritis
The world was still deep in the Great Depression when William Kaufman, MD, PhD had already begun treating osteoarthritis with two to four grams of niacinamide daily. Now, over 60 years later, his pioneering work in orthomolecular medicine is receiving the recognition it so well deserves.
In a 1978 radio interview with Carlton Fredericks, Dr Kaufman told of how "I had one patient who was so severely arthritic that I could not bend his elbows enough to measure his blood pressure. He was one of my first patients. I gave him niacinamide for a week in divided doses, and then he could bend his arm. I took him off it and gave him a look-alike medicine
(placebo). In a week he was back where he was before: his joints were stiff again.
"I arrived at my (megavitamin B-3 dosage) schedule by actually seeing the response of patients with varying degrees of arthritis. One cannot give a single large dose and get any really favorable results in arthritis... It is necessary to divide the doses so that the blood levels of niacinamide would be fairly uniform throughout the waking day."
Kaufman´s findings were both plain and elegant. The greater the stiffness, the more frequent the doses. Severely crippled arthritic patients needed up to a total of 4,000 mg/day. Divided into 10 doses per day, in one to three months, patients could now get out of their chair, or bed. "If continued, they would be able comb their hair and be able to walk upstairs, so they
would no longer be prisoners of the house. By the end of about three years treatment, they would be fully ambulatory, and this was even in the older age groups."
Common Forms of Niacinamide Deficiency Disease: Aniacinamidosis. New Haven, CT: Yale University Press. Also: The Common Form of Niacin Amide Deficiency Disease, Aniacinamidosis. By author, Bridgeport, CT., 1943
Niacinamide therapy for joint mobility. Conn. State Med. J. 17:584-589, 1953
Niacinamide, a most neglected vitamin. 1978 Tom Spies Memorial Lecture. J. Int. Acad. of Preventive Med. 8:5-25,1983
Niacinamide improves mobility in degenerative joint disease. Abstract published in Program of the American Association for the Advancement of Science for its meeting in Philadelphia, May 24-30, 1986
Reprinted from The Journal of Orthomolecular Medicine, Vol 16, Number 3, Third Quarter, 2001 (p 189).
Dr. Kaufman´s complete bibliography is posted at: